제품 이름
DC-Cholesterol HCl, Avanti Research™ - A Croda Brand 700001P, powder
assay
>99% (TLC)
form
powder
packaging
pkg of 1 × 1 g (700001P-1g), pkg of 1 × 200 mg (700001P-200mg), pkg of 1 × 25 mg (700001P-25mg), pkg of 1 × 500 mg (700001P-500mg)
manufacturer/tradename
Avanti Research™ - A Croda Brand 700001P
application(s)
vaccine development
shipped in
dry ice
storage temp.
−20°C
SMILES string
[H][C@](C1)(OC(NCC[N+](C)([H])C)=O)CC[C@@]2(C)C1=CC[C@]3([H])[C@]2([H])CC[C@@]4(C)[C@@]3([H])CC[C@]4([H])[C@@H](C)CCCC(C)C.[Cl-]
InChI
1S/C32H56N2O2.ClH/c1-22(2)9-8-10-23(3)27-13-14-28-26-12-11-24-21-25(36-30(35)33-19-20-34(6)7)15-17-31(24,4)29(26)16-18-32(27,28)5;/h11,22-23,25-29H,8-10,12-21H2,1-7H3,(H,33,35);1H
InChI key
ISXSJGHXHUZXNF-UHFFFAOYSA-N
General description
DC-Cholesterol HCl is a sterol-based transfection reagent.
DC-Cholesterol HCl is a cholesterol derivative and a cationic lipid with a head group and linker moiety.
Application
DC-Cholesterol HCl is suitable:
- for the preparation of ultrasound cationic microbubbles
- to prepare liposomes
- for the preparation of L-glutathione (GSH), loaded proliposomes
DC-Cholesterol HCl may be used in the preparation of colloidal dispersions for transmission electron microscopy studies. It may also be used in liposome preparation for assessing hexokinase activity, poly (lactic-coglycolicacid) loading and in mRNA transfection studies.
Biochem/physiol Actions
DC-Cholesterol is an effective transfection agent and a liposome reagent. Liposome of DC-Cholesterol with dioleoylphosphatidylethanolamine (DOPE) are efficient for DNA transfection. It imparts positive surface charge to the microbubbles for ultra sound based transfection of clustered regularly interspaced short palindromic repeats (CRISPRs).
DC-cholesterol is a cationic lipid, known to be the most efficient in gene transfection study.
Packaging
20 mL Clear Glass Screw Cap Vial (700001P-1g)
20 mL Clear Glass Screw Cap Vial (700001P-500mg)
5 mL Amber Glass Screw Cap Vial (700001P-200mg)
5 mL Amber Glass Screw Cap Vial (700001P-25mg)
Legal Information
Avanti Research is a trademark of Avanti Polar Lipids, LLC
저장 등급
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
C Colonna et al.
International journal of pharmaceutics, 364(1), 108-118 (2008-09-09)
The aim of this work was to investigate lipid-based dried powders as transfection competent carriers capable of promoting the expression of therapeutic genes. The lipid-based vectors were prepared by combining different cationic lipids 1,2-dioleoyl-3-trimethylammoniumpropane chloride (DOTAP), 1,2-dioleoyl-sn-glycero-3-phosphoethanolamine (DOPE), 1,2-dioleoyl-sn-glycero-3-phosphocholine (DOPC)
Modulation of yeast hexokinase on bio-inspired membranes
Umakoshi H and Nishida A
Biochemical Engineering Journal, 69(5), 138-143 (2012)
Cationic cage-like complexes formed by DC-cholesterol, Quil-A, and phospholipid
Lendemans DG, et al.
Journal of Pharmaceutical Sciences, 94(8), 1794-1807 (2005)
국제 무역 품목 번호
| SKU | GTIN |
|---|---|
| 700001P-200MG | 04061835184798 |
| 700001P-500MG | 04061835184811 |
| 700001P-1G | 04061835184781 |
| 700001P-25MG | 04061835184804 |