description
1,2-dioleoyl-sn-glycero-3-phosphoethanolamine
assay
>99% (TLC)
form
powder
packaging
pkg of 1 × 1 g (850725P-1g), pkg of 2 × 100 mg (850725P-200mg), pkg of 5 × 100 mg (850725P-500mg), pkg of 1 × 25 mg (850725P-25mg)
manufacturer/tradename
Avanti Research™ - A Croda Brand
application(s)
advanced drug delivery
lipid type
cardiolipins
phospholipids
shipped in
dry ice
storage temp.
−20°C
SMILES string
[H][C@@](COP([O-])(OCC[NH3+])=O)(OC(CCCCCCC/C=C\CCCCCCCC)=O)COC(CCCCCCC/C=C\CCCCCCCC)=O
InChI
1S/C41H78NO8P/c1-3-5-7-9-11-13-15-17-19-21-23-25-27-29-31-33-40(43)47-37-39(38-49-51(45,46)48-36-35-42)50-41(44)34-32-30-28-26-24-22-20-18-16-14-12-10-8-6-4-2/h17-20,39H,3-16,21-38,42H2,1-2H3,(H,45,46)/b19-17-,20-18-/t39-/m1/s1
InChI key
MWRBNPKJOOWZPW-NYVOMTAGSA-N
General description
1,2-dioleoyl-sn-glycero-3-phosphoethanolamine (18:1 (Δ9-Cis) PE (DOPE)) is a neutral phospholipid and displays sensitivity towards pH change. At acidic it is an inverted hexagonal micelle and transforms to spherical micelle at alkaline pH.
Application
18:1 (Δ9-Cis) PE (DOPE) has been used in the preparation of liposome for human uncoupling protein 1 (UCP1) reconstitution and for Caenorhabditis elegans autophagy related cysteine protease protein conjugation studies. It has also been used for the generation of giant unilamellar vesicles (GUVs) for septin induced deformation studies.
Biochem/physiol Actions
1,2-dioleoyl-sn-glycero-3-phosphoethanolamine (18:1 (Δ9-Cis) PE (DOPE)) forms a stable lipid layer and rapidly fuses with endosomal lipid bilayer. DOPE in combination with 1,2-dioleoyl-3-trimethylammonium-propane (DOTAP) has high in vitro transfection efficiency.
Packaging
20 mL Clear Glass Screw Cap Vial (850725P-1g)
5 mL Clear Glass Sealed Ampule (850725P-200mg)
5 mL Clear Glass Sealed Ampule (850725P-25mg)
5 mL Clear Glass Sealed Ampule (850725P-500mg)
Legal Information
Avanti Research is a trademark of Avanti Polar Lipids, LLC
저장 등급
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
Specific interaction of the human mitochondrial uncoupling protein 1 with free long-chain fatty acid
Zhao L, et al.
Structure, 25(9), 1371-1379 (2017)
Membrane reshaping by micrometric curvature sensitive septin filaments
Beber A, et al.
Nature Communications, 10(1), 420-420 (2019)
The role of the helper lipid on the DNA transfection efficiency of lipopolyplex formulations
Du Z, et al.
Scientific Reports, 4(2), 7107-7107 (2014)
국제 무역 품목 번호
| SKU | GTIN |
|---|---|
| 850725P-25MG | 04061835231218 |
| 850725P-500MG | 04061835231225 |
| 850725P-1G | 04061835231195 |
| 850725P-200MG | 04061835231201 |