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H1400000

Hydrocortisone 21-acetate

European Pharmacopoeia (EP) Reference Standard

Synonyme(s) :

21-acétate de 11β,17α,21-trihydroxy-4-pregnène-3,20-dione, 21-acétate de 17-hydroxycorticostérone, 21-acétate de 4-pregnène-11β,17α,21-triol-3,20-dione, Acétate de 17-α-hydroxycorticostérone

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A propos de cet article

Formule empirique (notation de Hill) :
C23H32O6
Numéro CAS:
50-03-3
Poids moléculaire :
404.50
UNSPSC Code:
41116107
NACRES:
NA.24
PubChem Substance ID:
329815160
MDL number:
MFCD00037714
Beilstein/REAXYS Number:
2066841
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grade

pharmaceutical primary standard

API family

hydrocortisone

manufacturer/tradename

EDQM

mp

223 °C (dec.) (lit.)

application(s)

pharmaceutical (small molecule)

format

neat

SMILES string

[H][C@@]12CCC3=CC(=O)CC[C@]3(C)[C@@]1([H])[C@@H](O)C[C@@]4(C)[C@@]2([H])CC[C@]4(O)C(=O)COC(C)=O

InChI

1S/C23H32O6/c1-13(24)29-12-19(27)23(28)9-7-17-16-5-4-14-10-15(25)6-8-21(14,2)20(16)18(26)11-22(17,23)3/h10,16-18,20,26,28H,4-9,11-12H2,1-3H3/t16-,17-,18-,20+,21-,22-,23-/m0/s1

InChI key

ALEXXDVDDISNDU-JZYPGELDSA-N

Gene Information

human ... NR3C1(2908)

General description

This product is provided as delivered and specified by the issuing Pharmacopoeia. All information provided in support of this product, including SDS and any product information leaflets have been developed and issued under the Authority of the Issuing Pharmacopoeia. For further information and support please go to the website of the issuing Pharmacopoeia.

Application

Hydrocortisone acetate EP Reference standard, intended for use in laboratory tests only as specifically prescribed in the European Pharmacopoeia.

Packaging

The product is delivered as supplied by the issuing Pharmacopoeia. For the current unit quantity, please visit the EDQM reference substance catalogue.

Other Notes

Sales restrictions may apply.

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pictograms

Health hazard
GHS08

signalword

Danger

Hazard Classifications

Repr. 1B - STOT RE 2

Classe de stockage

6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

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B Ramírez Andrade et al.
Journal of dairy science, 91(6), 2299-2306 (2008-05-20)
Lactation artificially induced (ART) by steroid hormones and natural lactation (NAT) after lambing were compared in 2 dairy sheep breeds (Manchega and Lacaune) in 2 experiments conducted during winter and spring. In experiment 1, ART ewes (14 Manchega and 9
Nunzia Falco et al.
International journal of pharmaceutics, 441(1-2), 589-597 (2012-11-06)
The objective of the present study was to develop an anti-inflammatory prolonged action formulation for local injection in prefilled syringes. Hydrocortisone acetate (HA) was selected as a model corticosteroid drug to be incorporated in poly(lactic-co-glycolic) (PLGA) microspheres. The formulation was
Alexander Reznikov et al.
Experimental and toxicologic pathology : official journal of the Gesellschaft fur Toxikologische Pathologie, 60(6), 489-497 (2008-08-12)
We investigated the effects of hydrocortisone acetate administered to pregnant rats over the last gestational week on some neuroendocrine characteristics in adult female and male offspring. Prenatal glucocorticoid eliminated sex dimorphism of the neurons nuclei volumes in the medial preoptic
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Numéro d'article de commerce international

RéférenceGTIN
H140000004061833811535