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H1425000

Hydrocortisone hydrogen succinate

European Pharmacopoeia (EP) Reference Standard

Synonyme(s) :

Hydrocortisone 21-hemisuccinate, 11β,17α,21-Trihydroxy-4-pregnene-3,20-dione 21-hemisuccinate, Cortisol 21-hemisuccinate

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A propos de cet article

Formule empirique (notation de Hill) :
C25H34O8
Numéro CAS:
2203-97-6
Poids moléculaire :
462.53
NACRES:
NA.24
PubChem Substance ID:
329815161
UNSPSC Code:
41116107
MDL number:
MFCD00046256
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grade

pharmaceutical primary standard

API family

hydrocortisone

manufacturer/tradename

EDQM

application(s)

pharmaceutical (small molecule)

format

neat

shipped in

wet ice

storage temp.

−20°C

SMILES string

C[C@]12CCC(=O)C=C1CC[C@H]3[C@@H]4CC[C@](O)(C(=O)COC(=O)CCC(O)=O)[C@@]4(C)C[C@H](O)[C@H]23

InChI

1S/C25H34O8/c1-23-9-7-15(26)11-14(23)3-4-16-17-8-10-25(32,24(17,2)12-18(27)22(16)23)19(28)13-33-21(31)6-5-20(29)30/h11,16-18,22,27,32H,3-10,12-13H2,1-2H3,(H,29,30)/t16-,17-,18-,22+,23-,24-,25-/m0/s1

InChI key

VWQWXZAWFPZJDA-CGVGKPPMSA-N

Gene Information

human ... NR3C1(2908)

General description

This product is provided as delivered and specified by the issuing Pharmacopoeia. All information provided in support of this product, including SDS and any product information leaflets have been developed and issued under the Authority of the issuing Pharmacopoeia.
For further information and support please go to the website of the issuing Pharmacopoeia.

Application

Hydrocortisone hydrogen succinate EP Reference standard, intended for use in laboratory tests only as specifically prescribed in the European Pharmacopoeia.

Packaging

The product is delivered as supplied by the issuing Pharmacopoeia. For the current unit quantity, please visit the EDQM reference substance catalogue.

Other Notes

Sales restrictions may apply.

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pictograms

Health hazard
GHS08

signalword

Danger

hcodes

H360D

Hazard Classifications

Repr. 1B

Classe de stockage

6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

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Lot/Batch Number

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Lucia Gagliardi et al.
The Journal of clinical endocrinology and metabolism, 99(11), 4149-4157 (2014-08-16)
Patients with Addison's disease (AD) report impaired subjective health status (SHS). Since cortisol exhibits a robust circadian cycle that entrains other biological clocks, impaired SHS may be due to the noncircadian cortisol profile achieved with conventional glucocorticoid replacement. Continuous subcutaneous
Takeshi Soma et al.
PloS one, 9(10), e110987-e110987 (2014-10-25)
We assessed the maintenance and distribution of epithelial stem/progenitor cells after corneal reconstruction using tissue-engineered oral mucosal cell sheets in a rat model. Oral mucosal biopsy specimens were excised from green fluorescent protein (GFP) rats and enzymatically treated with Dispase
Maureen Keller-Wood et al.
American journal of physiology. Regulatory, integrative and comparative physiology, 307(4), R405-R413 (2014-06-13)
In normal pregnancy, cortisol increases; however, further pathological increases in cortisol are associated with maternal and fetal morbidities. These experiments were designed to test the hypothesis that increased maternal cortisol would increase maternal glucose concentrations, suppress fetal growth, and impair
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Numéro d'article de commerce international

RéférenceGTIN
H142500004061833811542