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BP576

Hydrocortisone

British Pharmacopoeia (BP) Assay Standard

Synonyme(s) :

11β,17α,21-trihydroxypregn-4-ène-3,20-dione, 4-pregnène-11β,17α,21-triol-3,20-dione, Composé F de Kendall, Substance M de Reichstein

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A propos de cet article

Formule empirique (notation de Hill) :
C21H30O5
Numéro CAS:
50-23-7
Poids moléculaire :
362.46
NACRES:
NA.24
UNSPSC Code:
41116107
Beilstein/REAXYS Number:
1354819
MDL number:
MFCD00011654
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grade

pharmaceutical primary standard

API family

hydrocortisone

form

solid

shelf life

limited shelf life, expiry date on the label

manufacturer/tradename

BP

mp

211-214 °C (lit.)

application(s)

pharmaceutical
pharmaceutical small molecule

format

neat

SMILES string

[H][C@@]12CCC3=CC(=O)CC[C@]3(C)[C@@]1([H])[C@@H](O)C[C@@]4(C)[C@@]2([H])CC[C@]4(O)C(=O)CO

InChI

1S/C21H30O5/c1-19-7-5-13(23)9-12(19)3-4-14-15-6-8-21(26,17(25)11-22)20(15,2)10-16(24)18(14)19/h9,14-16,18,22,24,26H,3-8,10-11H2,1-2H3/t14-,15-,16-,18+,19-,20-,21-/m0/s1

InChI key

JYGXADMDTFJGBT-VWUMJDOOSA-N

Gene Information

human ... NR3C1(2908)

General description

This product is provided as delivered and specified by the issuing Pharmacopoeia. All information provided in support of this product, including SDS and any product information leaflets have been developed and issued under the Authority of the issuing Pharmacopoeia.
For further information and support please go to the website of the issuing Pharmacopoeia.

Application

Hydrocortisone BP Reference standard, intended for use in laboratory tests only as specifically prescribed in the British Pharmacopoeia.

Also used in monographs such as:
  • Tretinoin, Hydrocortisone and Hydroquinone Cream
  • Miconazole and Hydrocortisone Acetate Cream
  • Hydrocortisone Sodium Succinate Injection
  • Prednisolone Tablets
  • Miconazole and Hydrocortisone Cream
  • Miconazole and Hydrocortisone Ointment
  • Hydrocortisone and Neomycin Cream
  • Hydrocortisone and Clioquinol Ointment
  • Hydrocortisone Sodium Phosphate Oral Solution
  • Prednisolone Gastro-resistant Tablets
  • Hydrocortisone Sodium Phosphate
  • Hydrocortisone Sodium Phosphate Injection
  • Hydrocortisone and Clioquinol Cream
  • Methylprednisolone Tablets
  • Hydrocortisone Acetate Oral Suspension
  • Hydrocortisone Cream
  • Hydrocortisone Oromucosal Tablets

    • Biochem/physiol Actions

    Primary glucocorticoid secreted by the adrenal cortex. It has three times the anti-inflammatory potency of corticosterone but much lower Na2+ retention potency.
    Principal glucocorticoïde secrété par la glande cortico-surrénale.

    Other Notes

    Sales restrictions may apply.

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    pictograms

    Health hazard
    GHS08

    signalword

    Danger

    Hazard Classifications

    Repr. 1A - STOT RE 2

    target_organs

    Adrenal gland,Bone marrow

    Classe de stockage

    6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects

    wgk

    WGK 2

    flash_point_f

    Not applicable

    flash_point_c

    Not applicable

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    Certificats d'analyse (COA)

    Lot/Batch Number

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    Consulter la Bibliothèque de documents

    Karin E Koopman et al.
    Hepatology (Baltimore, Md.), 60(2), 545-553 (2014-03-29)
    American children consume up to 27% of calories from high-fat and high-sugar snacks. Both sugar and fat consumption have been implicated as a cause of hepatic steatosis and obesity but the effect of meal pattern is largely understudied. We hypothesized
    Marieke G N Bos et al.
    Psychoneuroendocrinology, 46, 102-113 (2014-06-03)
    Retrieval of negative emotional memories is often accompanied by the experience of stress. Upon retrieval, a memory trace can temporarily return into a labile state, where it is vulnerable to change. An unresolved question is whether post-retrieval stress may affect
    Nirit Geva et al.
    Pain, 155(11), 2418-2425 (2014-09-25)
    Anecdotes on the ability of individuals to continue to function under stressful conditions despite injuries causing excruciating pain suggest that acute stress may induce analgesia. However, studies exploring the effect of acute experimental stress on pain perception show inconsistent results
    Afficher tous les articles scientifiques apparentés

    Numéro d'article de commerce international

    RéférenceGTIN
    BP57604061835278206