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29208

(N-Succinimidyloxycarbonylmethyl)tris(2,4,6-trimethoxyphenyl)phosphonium bromide

Name: (N-Succinimidyloxycarbonylmethyl)tris(2,4,6-trimethoxyphenyl)phosphonium bromide
Brand: SIAL

for protein sequence analysis (by MALDI-MS), 98%

동의어(들):

N-Succinimidyl [tris(2,4,6-trimethoxyphenyl)phosphonio]acetate bromide, TMPP-Ac-OSu

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제품정보 (DICE 배송 시 비용 별도)

실험식(Hill 표기법):

C₃₃H₃₉BrNO₁₃P

CAS 번호:

226409-58-1

Molecular Weight:

768.54

NACRES:

NA.21

PubChem Substance ID:

329753320

UNSPSC Code:

41116105

MDL number:

MFCD03095505

Assay:

≥97.5% (HPLC), 98%

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도움 문의

속성

Quality Level

100

assay

≥97.5% (HPLC), 98%

technique(s)

MALDI-MS: suitable

storage temp.

−20°C

SMILES string

[Br-].COc1cc(OC)c(c(OC)c1)[P+](CC(=O)ON2C(=O)CCC2=O)(c3c(OC)cc(OC)cc3OC)c4c(OC)cc(OC)cc4OC

InChI

1S/C33H39NO13P.BrH/c1-38-19-12-22(41-4)31(23(13-19)42-5)48(18-30(37)47-34-28(35)10-11-29(34)36,32-24(43-6)14-20(39-2)15-25(32)44-7)33-26(45-8)16-21(40-3)17-27(33)46-9;/h12-17H,10-11,18H2,1-9H3;1H/q+1;/p-1

InChI key

YKMSQZIYVKTUHI-UHFFFAOYSA-M

설명

General description

N-Succinimidyloxycarbonylmethyl tris(2,4,6-trimethoxyphenyl)phosphonium bromide (TMPP-Ac-OSu) is an acylating reagent, and is generally used for the selective derivatization of N-terminal a-amino group of peptide. The TMPP-acetylated peptides undergo fragmentation thereby creating a-type ions, thus obtaining sequence information becomes easier, even without the usage of automated computational approach. It can be used as a labelling reagent in liquid chromatography-coupled mass spectrometry (LC-MS/MS) of N-terminal peptides, so as to improve ionization efficiency, simplify fragmentation, and retention times, thereby leading to better separation of peptides.

Application

TMPP-Ac-OSu was used for labelling peptides, in tandem mass spectrometry, done for converting arginine to ornithine, in order to improve the fragmentation pattern of peptides.

Packaging

Bottomless glass bottle. Contents are inside inserted fused cone.

Other Notes

Reagent for modifying N-termial of peptides for fast atom bombardment, FAB or matrix assisted laser desorption/ionization MS, MALDI MS

저장 등급

11 - Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

Eyeshields, Gloves, type N95 (US)

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시험 성적서(COA)

Lot/Batch Number

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문서 라이브러리 방문

Z. Huang et al.

Analytical Biochemistry, 69, 137-137 (1997)

Protein sequencing by matrix-assisted laser desorption ionization-postsource decay-mass spectrometry analysis of the N-Tris(2,4,6-trimethoxyphenyl)phosphine-acetylated tryptic digests.

Z H Huang et al.

Analytical biochemistry, 268(2), 305-317 (1999-03-17)

We have recently reported a simple procedure by which low picomole quantities of peptides can be modified to the corresponding N-Tris(2, 4,6-trimethoxyphenyl)phosphonium-acetyl (TMPP-Ac) derivatives (Z. H Huang, J. Wu, D. A. Gage, and J. T. Watson, Anal. Chem. 69, 137-144

Ortho-proteogenomics: multiple proteomes investigation through orthology and a new MS-based protocol.

Gallien S

Genome Research, 19 (1), 128-135 (2009)

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29208-50MG	04061826594391