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925225

KB02yne

Name: KB02yne
Brand: ALDRICH

동의어(들):

2-Chloro-1-(6-(hex-5-yn-1-yloxy)-3,4-dihydroquinolin-1(2H)-yl)ethan-1-one, Functionalized scout fragment

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보기 변경

제품정보 (DICE 배송 시 비용 별도)

실험식(Hill 표기법):

C₁₇H₂₀ClNO₂

CAS 번호:

2376152-06-4

Molecular Weight:

305.80

MDL number:

MFCD00003568

NACRES:

NA.22

UNSPSC Code:

12352101

기술 서비스

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도움 문의

속성

form

powder or crystals (or Solid or Liquid)

Quality Level

100

reaction suitability

reagent type: chemical modification reagent
reaction type: click chemistry

storage temp.

2-8°C

설명

Application

KB02yne is a cysteine-reactive small-molecule fragment for chemoproteomic and ligandability studies for both traditionally druggable proteins as well as ″undruggable,″ or difficult-to-target, proteins. This fragment electrophile is the functionalized version of KB02 (912131).

Related useful products may include:

Cysteine-reactive fragments: KB02 (912131), KB03 (912654), KB05 (911798), sulfoxide (925136), CoLDR probe (923818)
Functionalized scout fragments: KB02-COOH (925047), KB05yne (925144)
Electrophilc degraders featuring scout fragments: KB02-SLF (914738), KB03-SLF (914975), KB05-SLF (913715), Biotin-SLF (914223)
Cysteine-reactive probes for chemoproteomics: IA alkyne (924237), IA 5-TAMRA (925020), desthiobiotin iodoacetamide (923826), or biotin iodoacetamide (B2059)

Technology spotlight: Proteomic Ligandability Assessment

Other Notes

Functionalized Scout Fragments for Site-Specific Covalent Ligand Discovery and Optimization

The Proteome-Wide Potential for Reversible Covalency at Cysteine

Electrophilic PROTACs that degrade nuclear proteins by engaging DCAF16

저장 등급

10 - Combustible liquids

wgk

WGK 3

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시험 성적서(COA)

Lot/Batch Number

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문서 라이브러리 방문

The Proteome-Wide Potential for Reversible Covalency at Cysteine.

Kristine Senkane et al.

Angewandte Chemie (International ed. in English), 58(33), 11385-11389 (2019-06-22)

Reversible covalency, achieved with, for instance, highly electron-deficient olefins, offers a compelling strategy to design chemical probes and drugs that benefit from the sustained target engagement afforded by irreversible compounds, while avoiding permanent protein modification. Reversible covalency has mainly been

국제 무역 품목 번호

SKU	GTIN
925225-10MG	04065267461014