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925136

4,6-Dimethyl-2-(methylsulfinyl)-3-nitropyridine

Name: 4,6-Dimethyl-2-(methylsulfinyl)-3-nitropyridine
Brand: ALDRICH

동의어(들):

2-Sulfonylpyridine, Cysteine-reactive electrophile, S_NAr probe

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크기 선택

보기 변경

제품정보 (DICE 배송 시 비용 별도)

실험식(Hill 표기법):

C₈H₁₀N₂O₃S

CAS 번호:

2429964-95-2

Molecular Weight:

214.24

MDL number:

MFCD16251316

NACRES:

NA.22

UNSPSC Code:

12352200

기술 서비스

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도움 문의

속성

reaction suitability

reagent type: chemical modification reagent

Quality Level

100

storage temp.

2-8°C

설명

Application

4,6-Dimethyl-2-(methylsulfinyl)-3-nitropyridine is a sulfoxide-containing fragment for covalent ligand discovery via cysteine labeling as demonstrated by Zamboldo and coworkers. Fragment electrophiles are useful in chemoproteomic and ligandability studies for both traditionally druggable proteins as well as ″undruggable,″ or difficult-to-target, proteins.

Related useful products may include cysteine fragment KB02 (912131), IA alkyne (924237), IA 5-TAMRA (925020), desthiobiotin iodoacetamide (923826), or biotin iodoacetamide (B2059).

Other Notes

2-Sulfonylpyridines as Tunable, Cysteine-Reactive Electrophiles

저장 등급

11 - Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

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시험 성적서(COA)

Lot/Batch Number

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문서 라이브러리 방문

2-Sulfonylpyridines as Tunable, Cysteine-Reactive Electrophiles.

Claudio Zambaldo et al.

Journal of the American Chemical Society, 142(19), 8972-8979 (2020-04-18)

The emerging use of covalent ligands as chemical probes and drugs would benefit from an expanded repertoire of cysteine-reactive electrophiles for efficient and diverse targeting of the proteome. Here we use the endogenous electrophile sensor of mammalian cells, the KEAP1-NRF2

국제 무역 품목 번호

SKU	GTIN
925136-50MG	04065267468662
925136-100MG	04065267468655