42597
3′-Deoxythymidine 5′-triphosphate sodium salt solution
BioChemika, puriss. p.a., suitable for MALDI-MS, ≥98.0% (HPLC)
Synonyme(s) :
2′,3′-Dideoxythymidine 5′-triphosphate, ddTTP
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A propos de cet article
Formule empirique (notation de Hill) :
C10H16N2NaO13P3
Numéro CAS:
Poids moléculaire :
488.15
UNSPSC Code:
41116105
PubChem Substance ID:
MDL number:
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BioChemika
grade
puriss. p.a.
assay
≥98.0% (HPLC)
concentration
10.0-11.0 mmol/L (UV)
technique(s)
MALDI-MS: suitable
impurities
≤1.5% ddNDP (HPLC)
suitability
corresponds for UV test
storage temp.
−20°C
SMILES string
[Na+].CC1=CN([C@H]2CC[C@@H](COP([O-])(=O)OP(O)(=O)OP(O)(O)=O)O2)C(=O)NC1=O
InChI
1S/C10H17N2O13P3.Na/c1-6-4-12(10(14)11-9(6)13)8-3-2-7(23-8)5-22-27(18,19)25-28(20,21)24-26(15,16)17;/h4,7-8H,2-3,5H2,1H3,(H,18,19)(H,20,21)(H,11,13,14)(H2,15,16,17);/q;+1/p-1/t7-,8+;/m0./s1
InChI key
QJSZKDPCBDXBCK-KZYPOYLOSA-M
General description
3′-Deoxythymidine 5′-triphosphate sodium (ddTTP) is a sugar-modified dTTP analogue which is selective inhibitor of HIV-associated reverse transcriptase (HIV-RT). It is also seen to inhibit the activity of DNA polymerase α.
Packaging
packaging : 1 μmol (approx. 91-100 μL)
Classe de stockage
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
ppe
Eyeshields, Gloves, type N95 (US)
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Contenu apparenté
Elena N Ilina et al.
Frontiers in microbiology, 4, 186-186 (2013-07-13)
Spectinomycin remains a useful reserve option for therapy of gonorrhea. The emergence of multidrug-resistant Neisseria gonorrhoeae strains with decreased susceptibility to cefixime and to ceftriaxone makes it the only medicine still effective for treatment of gonorrhea infection in analogous cases.
Sylvia Steininger et al.
Nucleic acids research, 38(6), 1853-1865 (2009-12-31)
The Mre11/Rad50/Xrs2 (MRX) complex in Saccharomyces cerevisiae has well-characterized functions in DNA double-strand break processing, checkpoint activation, telomere length maintenance and meiosis. In this study, we demonstrate an involvement of the complex in the base excision repair (BER) pathway. We
Konstantin Akopiants et al.
Nucleic acids research, 42(5), 3125-3137 (2013-12-29)
To track the processing of damaged DNA double-strand break (DSB) ends in vivo, a method was devised for quantitative measurement of 3'-phosphoglycolate (PG) termini on DSBs induced by the non-protein chromophore of neocarzinostatin (NCS-C) in the human Alu repeat. Following
Numéro d'article de commerce international
| Référence | GTIN |
|---|---|
| 42597-1UMO-F | 04061833627129 |