902683
BocNH-PEG5-acid
Synonyme(s) :
2,2-Dimethyl-4-oxo-3,8,11,14,17,20-hexaoxa-5-azadocosan-22-oic acid, Boc-NH-PEG5-CH2COOH
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A propos de cet article
Formule empirique (notation de Hill) :
C17H33NO9
Numéro CAS:
Poids moléculaire :
395.45
MDL number:
UNSPSC Code:
12352106
NACRES:
NA.22
Form:
liquid
Service technique
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liquid
reaction suitability
reaction type: Pegylations, reagent type: cross-linking reagent
functional group
Boc, amine, carboxylic acid
storage temp.
−20°C
SMILES string
OC(COCCOCCOCCOCCOCCNC(OC(C)(C)C)=O)=O
InChI
1S/C17H33NO9/c1-17(2,3)27-16(21)18-4-5-22-6-7-23-8-9-24-10-11-25-12-13-26-14-15(19)20/h4-14H2,1-3H3,(H,18,21)(H,19,20)
InChI key
OLLNIAGWMCSEJB-UHFFFAOYSA-N
Application
This heterobifunctional, PEGylated crosslinker features a carboxylic acid at one end and Boc-protected amino group at the other, which can be deprotected with mildly acidic conditions. The hydrophilic PEG linker facilitates solubility in biological applications. BocNH-PEG5-acid can be used for bioconjugation or as a building block for synthesis of small molecules, conjugates of small molecules and/or biomolecules, or other tool compounds for chemical biology and medicinal chemistry that require ligation. Examples of applications include its synthetic incorporation into antibody-drug conjugates or proteolysis-targeting chimeras (PROTAC® molecules) for targeted protein degradation.
Technology Spotlight: Degrader Building Blocks for Targeted Protein Degradation
Technology Spotlight: Degrader Building Blocks for Targeted Protein Degradation
Legal Information
PROTAC is a registered trademark of Arvinas Operations, Inc., and is used under license
Classe de stockage
10 - Combustible liquids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
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Miyuki Mabuchi et al.
Bioorganic & medicinal chemistry letters, 25(16), 3373-3377 (2015-06-24)
This Letter presents an effective method for the identification of target proteins of bioactive compounds such as drugs, natural products, and intrinsic ligands, using an affinity resin. The application of a photo-labile linker to an affinity resin enabled the selective
Numéro d'article de commerce international
| Référence | GTIN |
|---|---|
| 902683-1G | 04061838694706 |
| 902683-250MG | 04061838694713 |