902675
BocNH-PEG6-acid
Synonyme(s) :
2,2-Dimethyl-4-oxo-3,8,11,14,17,20,23-heptaoxa-5-azapentacosan-25-oic acid, Boc-NH-PEG6-CH2COOH
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A propos de cet article
Formule empirique (notation de Hill) :
C19H37NO10
Numéro CAS:
Poids moléculaire :
439.50
UNSPSC Code:
12352106
NACRES:
NA.22
MDL number:
Form:
liquid
Service technique
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liquid
reaction suitability
reagent type: linker
refractive index
n/D 1.4657
functional group
Boc, amine, carboxylic acid
storage temp.
−20°C
SMILES string
OC(COCCOCCOCCOCCOCCOCCNC(OC(C)(C)C)=O)=O
InChI
1S/C19H37NO10/c1-19(2,3)30-18(23)20-4-5-24-6-7-25-8-9-26-10-11-27-12-13-28-14-15-29-16-17(21)22/h4-16H2,1-3H3,(H,20,23)(H,21,22)
InChI key
ZKCDWMFMVAYYED-UHFFFAOYSA-N
Application
This heterobifunctional, PEGylated crosslinker features a carboxylic acid at one end and Boc-protected amino group at the other, which can be deprotected with mildly acidic conditions. The hydrophillic PEG linker facilitates solubility in biological applications. BocNH-PEG6-acid can be used for bioconjugation or as a building block for synthesis of small molecules, conjugates of small molecules and/or biomolecules, or other tool compounds for chemical biology and medicinal chemistry that require ligation. Examples of applications include its synthetic incorporation into antibody-drug conjugates or proteolysis-targeting chimeras (PROTAC® molecules) for targeted protein degradation.
Other Notes
Legal Information
PROTAC is a registered trademark of Arvinas Operations, Inc., and is used under license
Classe de stockage
10 - Combustible liquids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
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Vincent Rerat et al.
Bioorganic & medicinal chemistry letters, 20(6), 1861-1865 (2010-02-23)
Ultrasmall particles of iron oxide (USPIOs) coated with 3,3'-bis(phosphonate)propionic acid were covalently coupled to a home-made Arg-Gly-Asp (RGD) peptidomimetic molecule via a short oligoethylene-glycol (OEG) spacer. The conjugation rate was measured by X-ray photoelectron spectroscopy (XPS). The particle size and
Vincent Rerat et al.
Journal of medicinal chemistry, 52(22), 7029-7043 (2009-10-29)
RGD peptides are used in biomaterials science for surface modifications with a view to elicit selective cellular responses. Our objective is to replace peptides by small peptidomimetics acting similarly. We designed novel molecules targeting alpha(v)beta(3) integrin and featuring spacer-arms (for
Numéro d'article de commerce international
| Référence | GTIN |
|---|---|
| 902675-1G | 04061838694614 |
| 902675-250MG | 04061838694676 |