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Merck

1437202

USP

Methylpyrrolidone

United States Pharmacopeia (USP) Reference Standard

동의어(들):

1-Methyl-2-pyrrolidinone, 1-Methyl-2-pyrrolidone, N-Methyl-2-pyrrolidone, NMP

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제품정보 (DICE 배송 시 비용 별도)

실험식(Hill 표기법):
C5H9NO
CAS 번호:
Molecular Weight:
99.13
UNSPSC Code:
41116107
NACRES:
NA.24
PubChem Substance ID:
MDL number:
Beilstein/REAXYS Number:
106420
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grade

pharmaceutical primary standard

vapor density

3.4 (vs air)

vapor pressure

0.29 mmHg ( 20 °C), 0.99 mmHg ( 40 °C)

form

liquid

autoignition temp.

518 °F

expl. lim.

9.5 %

manufacturer/tradename

USP

refractive index

n20/D 1.47 (lit.)

bp

202 °C (lit.), 81-82 °C/10 mmHg (lit.)

mp

−24 °C (lit.)

density

1.028 g/mL at 25 °C (lit.)

application(s)

USP Biologics
pharmaceutical (small molecule)

format

neat

SMILES string

CN1CCCC1=O

InChI

1S/C5H9NO/c1-6-4-2-3-5(6)7/h2-4H2,1H3

InChI key

SECXISVLQFMRJM-UHFFFAOYSA-N

General description

Methylpyrrolidone is a highly polar solvent used in biologics formulations, particularly for drugs that require solubilization of hydrophobic compounds. It facilitates the delivery and stability of poorly soluble biologics by enhancing their dissolution properties. NMP is widely used in drug delivery systems, contributing to more efficient therapeutic delivery.

The United States Pharmacopeia (USP) provides quality standards for biologics to ensure their safety, efficacy, and quality throughout the manufacturing process. These standards assist manufacturers in adhering to regulatory requirements and help safeguard public health by reducing risks associated with biologics.

This compound is listed in the SVHC (Substances of very high concern) candidate list of ECHA (European Chemicals Agency)
This product is provided as delivered and specified by the issuing Pharmacopoeia. All information provided in support of this product, including SDS and any product information leaflets have been developed and issued under the Authority of the issuing Pharmacopoeia.
For further information and support please go to the website of the issuing Pharmacopoeia.

Application

Methylpyrrolidone USP reference standard, intended for use in specified quality tests and assays as specified in the USP compendia.

Analysis Note

These products are for test and assay use only. They are not meant for administration to humans or animals and cannot be used to diagnose, treat, or cure diseases of any kind.  ​

Other Notes

Sales restrictions may apply.
This compound is listed in the SVHC (Substances of very high concern) candidate list of ECHA (European Chemicals Agency)This product is provided as delivered and specified by the issuing Pharmacopoeia. All information provided in support of this product, including SDS and any product information leaflets have been developed and issued under the Authority of the issuing Pharmacopoeia. For further information and support please go to the website of the issuing Pharmacopoeia.
This product is part of USP Biologics Program.
This product is provided as delivered and specified by the issuing Pharmacopoeia. All information provided in support of this product, including SDS and any product information leaflets have been developed and issued under the Authority of the issuing Pha


pictograms

Health hazardExclamation mark

signalword

Danger

Hazard Classifications

Eye Irrit. 2 - Repr. 1B - Skin Irrit. 2 - STOT SE 3

target_organs

Respiratory system

저장 등급

6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects

wgk

WGK 1

flash_point_f

195.8 °F - Pensky-Martens closed cup

flash_point_c

91 °C - Pensky-Martens closed cup



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Ryo Matsumoto et al.
Scientific reports, 5, 12884-12884 (2015-08-11)
Peptides, especially intracellular functional peptides that can play a particular role inside a cell, have attracted attention as promising materials to control cell fate. However, hydrophilic materials like peptides are difficult for cells to internalize. Therefore, the screening and design



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SKUGTIN
1437202-2G04061838735058