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T6031

DL-Thiorphan

Name: <SC>DL</SC>-Thiorphan
Brand: SIGMA

≥98% (TLC), Enkephalinase inhibitor., powder

동의어(들):

(±)-N-(3-Mercapto-2-benzylpropionyl)glycine, DL-3-Mercapto-2-benzylpropanoylglycine

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제품정보 (DICE 배송 시 비용 별도)

실험식(Hill 표기법):

C₁₂H₁₅NO₃S

CAS 번호:

76721-89-6

Molecular Weight:

253.32

NACRES:

NA.77

PubChem Substance ID:

24278747

UNSPSC Code:

12352200

MDL number:

MFCD00058435

Beilstein/REAXYS Number:

4872101

Assay:

≥98% (TLC)

Form:

powder

Quality level:

200

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속성

제품 이름

DL-Thiorphan, ≥98% (TLC)

Quality Level

200

assay

≥98% (TLC)

form

powder

mp

138 °C

solubility

ethanol: soluble 49.00-51.00 mg/mL, clear, colorless

SMILES string

OC(=O)CNC(=O)C(CS)Cc1ccccc1

InChI

1S/C12H15NO3S/c14-11(15)7-13-12(16)10(8-17)6-9-4-2-1-3-5-9/h1-5,10,17H,6-8H2,(H,13,16)(H,14,15)

InChI key

LJJKNPQAGWVLDQ-UHFFFAOYSA-N

Gene Information

human ... ACE(1636), ECE1(1889)
rat ... Ace(24310), Mme(24590)

설명

General description

Thiorphan, also called DL-mercapto-2-benzylpropanoyl-glycine is a specific and potent inhibitor of enkephalinase in nanomolar concentrations. It is an inhibitor of neutral endopeptidase. It interacts with cluster of differentiation 10 (CD10) in bone marrow cells and may modulate hematopoiesis. Thiorphan is a safe drugprescribed for diarrhea. It prevents cortical damage in newborn mice and is a potent agent for treating cerebral palsy.(CP)

Application

DL-Thiorphan has been used to evaluate the activity of NEP-dependent neutral endopeptidase. DL-Thiorphan has also been used for determining NEP enzymatic activity using fluorimetric assays.

Biochem/physiol Actions

Enkephalinase inhibitor.

Features and Benefits

This compound is featured on the Neuropeptidases page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.

Preparation Note

DL-Thiorphan is soluble in ethanol at 49.00 - 51.00 mg/ml and yields a clear, colorless solution.

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저장 등급

11 - Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

Eyeshields, Gloves, type N95 (US)

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문서 라이브러리 방문

The enkephalinase inhibitor thiorphan shows antinociceptive activity in mice

Roques BP, et al.

Nature, 288(5788), 286-288 (1980)

Thiorphan, a neutral endopeptidase inhibitor used for diarrhoea, is neuroprotective in newborn mice

Medja F, et al.

Brain, 129(12), 3209-3223 (2006)

Global brain delivery of neprilysin gene by intravascular administration of AAV vector in mice

Iwate N, et al.

Scientific Reports (2013)

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국제 무역 품목 번호

SKU	GTIN
T6031-5MG	04061832949963
T6031-25MG	04061832949956