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T2376

L-Thyroxine

Name: <SC>L</SC>-Thyroxine
Brand: SIGMA

synthetic, ≥98% (HPLC), Metabolism activator, powder

동의어(들):

3,3′,5,5″-Tetraiodo-L-thyronine, 3-[4-(4-Hydroxy-3,5-diiodophenoxy)-3,5-diiodophenyl]-L-alanine, T₄

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제품정보 (DICE 배송 시 비용 별도)

Linear Formula:

HOC₆H₂(I)₂OC₆H₂(I)₂CH₂CH(NH₂)CO₂H

CAS 번호:

51-48-9

Molecular Weight:

776.87

NACRES:

NA.32

PubChem Substance ID:

24900033

UNSPSC Code:

51111800

EC Number:

200-101-1

MDL number:

MFCD00002595

Beilstein/REAXYS Number:

2228515

eCl@ss:

32190102

Biological source:

synthetic

Form:

powder

Assay:

≥98% (HPLC)

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속성

제품 이름

L-Thyroxine, ≥98% (HPLC)

biological source

synthetic

Quality Level

200

sterility

non-sterile

assay

≥98% (HPLC)

form

powder

technique(s)

cell culture | mammalian: suitable

mp

223 °C (dec.) (lit.)

solubility

4 M NH₄OH in methanol: 50 mg/mL, clear to hazy, yellow

shipped in

ambient

storage temp.

room temp

SMILES string

N[C@@H](Cc1cc(I)c(Oc2cc(I)c(O)c(I)c2)c(I)c1)C(O)=O

InChI

1S/C15H11I4NO4/c16-8-4-7(5-9(17)13(8)21)24-14-10(18)1-6(2-11(14)19)3-12(20)15(22)23/h1-2,4-5,12,21H,3,20H2,(H,22,23)/t12-/m0/s1

InChI key

XUIIKFGFIJCVMT-LBPRGKRZSA-N

Gene Information

human ... THRA(7067), THRB(7068), TTR(7276)
mouse ... Cnr2(12802)
rat ... Cnr1(25248)

설명

Application

L-Thyroxine was used to study the light-induced hormone conversion of T4 to T3 in regulation of photoperiodic response of gonads in Japanese quail. The product was used as a test compound for studying the impact of numerous hormones on the surface morphology of rat testicular cells in culture.

Biochem/physiol Actions

L-Thyroxine (T₄) and triiodo-L-thyronine (T₃) are iodine-containing hormones produced from thyroglobulin in the thyroid follicular cells. The stimulation of metabolic rate and regulation of growth and development by these hormones appear to be due to their effects on DNA transcription and, thus, protein synthesis.

L-Thyroxine is an iodine containing hormone produced from thyroglobulin in the thyroid follicular cells. L-Thyroxine reduces total cholesterol level, low-density lipoprotein cholesterol as well as waist to hip ratio in subclinical hypothyroidism pateints. Hence, facilitates in improving cardiovascular risk factor as well as can enhance symptoms of tiredness.

Packaging

Bottomless glass bottle. Contents are inside inserted fused cone.

Preparation Note

L-Thyroxine dissolves in 4M ammonium hydroxide in Methanol at 50 mg/ml to yield a clear to hazy yellow to dark yellow solution.

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pictograms

GHS08

signalword

Danger

hcodes

H372

pcodes

P260 - P264 - P270 - P314 - P501

Hazard Classifications

STOT RE 1

target_organs

Thyroid,Cardio-vascular system,Kidney

저장 등급

6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

Eyeshields, Gloves, type N95 (US)

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문서 라이브러리 방문

The effects of various hormones on the surface morphology of testicular cells in culture.

J C Hutson

The American journal of anatomy, 151(1), 55-69 (1978-01-01)

The purpose of this investigation was to study the effects of various hormones on the surface morphology of 20-day-old rat testicular cells in culture. Aggregates containing primarily Sertoli cells and germinal cells were obtained by enzymatic digestion. The surface morphology

Light-induced hormone conversion of T4 to T3 regulates photoperiodic response of gonads in birds.

Takashi Yoshimura et al.

Nature, 426(6963), 178-181 (2003-11-14)

Reproduction of many temperate zone birds is under photoperiodic control. The Japanese quail is an excellent model for studying the mechanism of photoperiodic time measurement because of its distinct and marked response to changing photoperiods. Studies on this animal have

The beneficial effect of L-thyroxine on cardiovascular risk factors, endothelial function, and quality of life in subclinical hypothyroidism: randomized, crossover trial.

Salman Razvi et al.

The Journal of clinical endocrinology and metabolism, 92(5), 1715-1723 (2007-02-15)

Subclinical hypothyroidism (SCH) is defined as raised serum TSH levels with circulating thyroid hormones within the reference range. It is uncertain whether treatment of SCH with L-thyroxine improves cardiovascular (CV) risk factors and quality of life. The objective of the

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국제 무역 품목 번호

SKU	GTIN
T2376-500MG	04061837342035
T2376-5G	04061837342066
T2376-100MG	04061837342004
T2376-1G	04061837342028