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SRE0023

β-Glucuronidase from abalone

Name: β-Glucuronidase from abalone
Brand: SIGMA

Purified, aqueous solution, β-glucuronidase 150,000-250,000 units/mL, β-glucuronidase ≥20,000,000 units/g protein

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제품정보 (DICE 배송 시 비용 별도)

UNSPSC Code:

12352204

NACRES:

NA.54

EC 번호:

3.1.2.31 (BRENDA, IUBMB)

MDL number:

MFCD00130629

기술 서비스

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도움 문의

속성

Quality Level

200

form

aqueous solution

β-glucuronidase activity

≥20,000,000 units/g protein, 150,000-250,000 units/mL

secondary activity

≤7,500 units/mL sulfatase

storage temp.

2-8°C

설명

Application

Technical Article Comparing Performance of Different Enzymes
Learn more
about recent application data generated by Sigma R&D to optimize hydrolysis for different drug classes using enzymes from different sources and the use of a chromatographicaly purified enzyme to reduce the effect of esterase activity resulting in conversion of 6-MAM to Morphine.

Biochem/physiol Actions

β-Glucuronidase (GUSB) is a lysosomal enzyme, that degrades glucuronate-containing glycosaminoglycans. β-glucuronidase, obtained from abalone has the ability to hydrolyze samples, that has high analyte concentrations. Absence of β-glucuronidase results in mucopolysaccharidosis type VII (MPSVII), which leads to lysosomal storage in the brain.

Physical form

Supplied as an aqueous solution containing L-proline, ammonium acetate and sodium azide

Other Notes

One Sigma or modified Fishman unit will liberate 1.0 μg of phenolphthalein from phenolphthalein glucuronide per hr at 37 °C at pH 3.8 (30 min assay).

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저장 등급

10 - Combustible liquids

wgk

nwg

flash_point_f

Not applicable

flash_point_c

Not applicable

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시험 성적서(COA)

Lot/Batch Number

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문서 라이브러리 방문

문서

Evaluation of Different Enzymes on Hydrolysis Efficiencies of Glucuronide Drug Metabolites in Urine

β-glucuronidase (GUS) enzymes are utilized to hydrolyze glucuronide (gluc) drug metabolites to the parent drug, facilitating analysis by LC-MS/MS.

Evaluation of abalone beta-glucuronidase substitution in current urine hydrolysis procedures

Malik W B, et al.

Journal of Analytical Toxicology, 38(3), 171-176 (2014)

Human beta-glucuronidase: structure, function, and application in enzyme replacement therapy

Naz H, et al.

Rejuvenation Research, 16(5), 352-363 (2013)

국제 무역 품목 번호

SKU	GTIN
SRE0023-50ML	04061838114938
SRE0023-10ML	04061837108914
SRE0023-25ML	04061838037893