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SML1236

(−)-Nicotine hydrogen tartrate salt

≥98% (HPLC), acetylcholine receptor agonist, powder

동의어(들):

(−)-Nicotine ditartrate, (−)-1-Methyl-2-(3-pyridyl)pyrrolidine (+)-bitartrate salt

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제품정보 (DICE 배송 시 비용 별도)

실험식(Hill 표기법):
C10H14N2 · 2C4H6O6
CAS 번호:
65-31-6
Molecular Weight:
462.41
UNSPSC Code:
12352210
PubChem Substance ID:
329825736
NACRES:
NA.77
EC Number:
200-607-2
Assay:
≥98% (HPLC)
Form:
powder
Quality level:
100
Storage condition:
desiccated
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제품 이름

(−)-Nicotine hydrogen tartrate salt, ≥98% (HPLC)

Quality Level

100

assay

≥98% (HPLC)

form

powder

optical activity

[α]/D +20 to +26°, c = 1.0 in water

storage condition

desiccated

color

white to beige

solubility

H2O: 20 mg/mL, clear

storage temp.

room temp

SMILES string

CN1CCC[C@H]1C2=CC=CN=C2.C

InChI

1S/C10H14N2.CH4/c1-12-7-3-5-10(12)9-4-2-6-11-8-9;/h2,4,6,8,10H,3,5,7H2,1H3;1H4/t10-;/m0./s1

InChI key

RYYKFQGHMYGLEL-PPHPATTJSA-N

Application

(−)-Nicotine hydrogen tartrate salt has been used in intracellular calcium imaging.
(−)-Nicotine hydrogen tartrate salt has been used as an agonist for acetylcholine receptor (AChr).

Biochem/physiol Actions

Prototype nicotinic acetylcholine receptor agonist; naturally occurring isomer.
NHT is considered to be more stable than nicotine. Nicotine is highly addictive drug and is indirectly but strongly associated with tobacco related diseases. It helps to discontinue smoking. Nicotine might serve as a therapeutic agent in treating Alzheimer’s disease, Parkinson’s disease and ulcerative colitis.

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Danger

Hazard Classifications

Acute Tox. 2 Inhalation - Acute Tox. 3 Oral - Aquatic Chronic 2 - Eye Irrit. 2 - Repr. 2

저장 등급

6.1A - Combustible acute toxic Cat. 1 and 2 / very toxic hazardous materials

wgk

WGK 2

flash_point_f

289.8 °F

flash_point_c

143.2 °C

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시험 성적서(COA)

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문서 라이브러리 방문

Metabolism and disposition kinetics of nicotine.
Hukkanen J, et al.
Pharmacological Reviews, 57(1), 79-115 (2005)
Mahmoud M Farag et al.
European journal of pharmacology, 720(1-3), 1-6 (2013-11-12)
The aim of this study was to evaluate the effects of chronic nicotine administration on bone mineral homeostasis in rapidly growing young rats in comparison to effects in adult male rats. Two doses of nicotine (3 and 4.5mg/kg/day, as nicotine
Ozra Dehkordi et al.
Journal of neuroscience research, 93(2), 230-243 (2014-09-17)
Direct actions of nicotine in the CNS appear to be essential for its reinforcing properties. However, activation of nicotinic acetylcholine receptors (nAChRs) on afferent sensory nerve fibers is an important component of addiction to, and withdrawal from, cigarette smoking. The
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국제 무역 품목 번호

SKUGTIN
SML1236-1G04061825983561
SML1236-50MG04061837107757