SML0035
Tiagabine hydrochloride
≥98% (HPLC)
동의어(들):
(-)-(R)-1-[4,4-bis(3-methyl-2-thienyl)-3-butenyl]nipecotic acid hydrochloride, (3R)-1-[4,4-Bis(3-methyl-2-thienyl)-3-buten-1-yl]-3-piperidinecarboxylic acid hydrochloride
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크기 선택
보기 변경
제품정보 (DICE 배송 시 비용 별도)
실험식(Hill 표기법):
C20H25NO2S2 · HCl
CAS 번호:
Molecular Weight:
412.01
NACRES:
NA.77
PubChem Substance ID:
UNSPSC Code:
12352200
MDL number:
Quality Level
assay
≥98% (HPLC)
form
powder
optical activity
[α]/D -9 to -12°, c = 1 in H2O
color
white to beige
solubility
H2O: 10 mg/mL, clear
originator
Cephalon
storage temp.
2-8°C
SMILES string
Cl.Cc1ccsc1C(=CCCN2CCC[C@H](C2)C(O)=O)c3sccc3C
InChI
1S/C20H25NO2S2.ClH/c1-14-7-11-24-18(14)17(19-15(2)8-12-25-19)6-4-10-21-9-3-5-16(13-21)20(22)23;/h6-8,11-12,16H,3-5,9-10,13H2,1-2H3,(H,22,23);1H/t16-;/m1./s1
InChI key
YUKARLAABCGMCN-PKLMIRHRSA-N
Gene Information
human ... SLC6A1(6529)
Application
Tiagabine hydrochloride was used to study serotoninergic transmission in G1 cells. It has also been used to study its anti-aging effects on the sensory neurons of C. elegans.
Biochem/physiol Actions
Selective inhibitor of the synaptic GABA transporter GAT1; Anticonvulsant
Tiagabine hydrochloride is an anticonvulsant and selective GABA reuptake inhibitor through inhibition of the synaptic GABA transporter GAT1.
Tiagabine increases the synaptic GABA and enhances the neuronal inhibition. It is effective as adjunctive treatment of epilepsy and anxiety disorders.
Features and Benefits
This compound is a featured product for Neuroscience research. Click here to discover more featured Neuroscience products. Learn more about bioactive small molecules for other areas of research at sigma.com/discover-bsm.
This compound is featured on the GABA Transporters page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.
This compound was developed by Cephalon. To browse the list of other pharma-developed compounds and Approved Drugs/Drug Candidates, click here.
저장 등급
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
문서
DISCOVER Bioactive Small Molecules for Neuroscience
신경과학을 위한 생체 활성 저분자
An automated compound screening for anti-aging effects on the function of C. elegans sensory neurons
Bazopoulou D, et al.
Scientific Reports (2017)
Gang Zhao et al.
European neuropsychopharmacology : the journal of the European College of Neuropsychopharmacology, 19(10), 749-758 (2009-07-07)
Safflower, the dry flower of Carthamus tinctorius L., has long been applied for empirically treating cerebral ischemia and depression in traditional Chinese medicine. Pathogenesis of major depression involves monoaminergic transmission. The present study assessed whether safflower or its isolate would
Andrea Eugenio Cavanna et al.
Discovery medicine, 9(45), 138-144 (2010-03-03)
Anti-epileptic drugs (AEDs) have a variety of mechanisms of action which are reflected through different anticonvulsant activities and behavioral effects. Two categories of AEDs are considered based on psychotropic profile. The first group is characterized by potentiation of gamma-aminobutyric acid
국제 무역 품목 번호
| SKU | GTIN |
|---|---|
| SML0035-10MG | 04061837076602 |
| SML0035-50MG | 04061837076619 |