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Merck

SAB5300387

Monoclonal Anti-RET antibody produced in mouse

clone 8D10C9, ascites fluid

동의어(들):

RET

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제품정보 (DICE 배송 시 비용 별도)

NACRES:
NA.41
UNSPSC Code:
12352203
Conjugate:
unconjugated
Clone:
8D10C9, monoclonal
Application:
ELISA (d), WB
Citations:
5
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biological source

mouse

Quality Level

conjugate

unconjugated

antibody form

ascites fluid

antibody product type

primary antibodies

clone

8D10C9, monoclonal

species reactivity

human

technique(s)

direct ELISA: 1:10,000, western blot: 1:500-1:2,000

isotype

IgG1

UniProt accession no.

shipped in

wet ice

storage temp.

−20°C

target post-translational modification

unmodified

Gene Information

human ... RET(5979)

General description

The RET (rearranged during transfection) proto-oncogene is mapped to human chromosome 10q11. It has two isoforms, namely RET9 and RET51 with unique C-terminal tail sequences. RET is made of 20 exons and 21 introns.

Immunogen

Purified recombinant fragment of RET (aa896-1063) expressed in E.coli.
Mouse monoclonal antibody raised against RET

Biochem/physiol Actions

The RET (rearranged during transfection) is involved in signal transduction pathways related to cell proliferation and differentiation. Mutations in RET gene results in medullary thyroid carcinoma and Hirschsprung′s disease. It is involved in normal development and cancer. The isoforms of RET provides distinct protein complexes to promote signals.

Physical form

Ascitic fluid containing 0.03% sodium azide.

Disclaimer

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.


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저장 등급

10 - Combustible liquids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable



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시험 성적서(COA)

Lot/Batch Number

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문서 라이브러리 방문



Differential recruitment of E3-ubiquitin ligase complexes regulates RET isoform internalization.
Hyndman BD, et al.
Journal of Cell Science, 130(19), 3282-3296 (2017)
Associations between RET tagSNPs and their haplotypes and susceptibility, clinical severity, and thyroid function in patients with differentiated thyroid cancer.
He C, et al.
PLoS ONE, 12(11), e0187968-e0187968 (2017)
Marjan Zarif Yeganeh et al.
Asian Pacific journal of cancer prevention : APJCP, 16(6), 2107-2117 (2015-04-01)
Thyroid cancer is the most common endocrine neoplasia. The medullary thyroid carcinoma (MTC) is one of the most aggressive forms of thyroid malignancy,accounting for up to 10% of all types of this disease. The mode of inheritance of MTC is



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SKUGTIN
SAB5300387-100UL04061837600593