Monoclonal Anti-CD71-PE antibody produced in mouse

Cluster of differentiation 71 (CD71), also known as transferrin receptor, is encoded by the gene mapped to human chromosome 3q29. CD71 is present on cells with high proliferation.

The antibody MEM-75 reacts with CD71 antigen (transferrin receptor), a 95 kDa type II homodimeric transmembrane glycoprotein expressed on activated B and T lymphocytes, macrophages and erythroid precursors; it is lost on resting blood leukocytes.

NALM-6 human pre-B cell line

Monoclonal Anti-CD71-PE antibody produced in mouse has been used to estimate the cell surface transferrin receptor (TfR) levels.

The reagent is designed for Flow Cytometry analysis of human blood cells using 20 μL reagent / 100 μL of whole blood or 1e6 cells in a suspension. The content of a vial (2 mL) is sufficient for 100 tests.

Cluster of differentiation 71 (CD71) functions as an iron regulatory protein. Overexpression of the gene has been associated with the development of various types of cancers, including cholangiocarcinoma (CCA). Thus, CD71 protein is considered as a potential therapeutic target for CCA and iron overload. The encoded protein facilitates mitochondrial respiration and reactive oxygen species (ROS) production in human pancreatic ductal adenocarcinoma (PDAC) cells, which is essential for their tumorigenic growth. Thus, aberrant expression of CD71 might also lead to the development of pancreatic cancer.

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Solution in phosphate buffered saline containing 15 mM sodium azide and 0.2% high-grade protease free BSA as a stabilizing agent.

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