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S6883

Substance P acetate salt hydrate

Name: Substance P acetate salt hydrate
Brand: SIGMA

≥95% (HPLC), NK-1 agonist, powder

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제품정보 (DICE 배송 시 비용 별도)

실험식(Hill 표기법):

C₆₃H₉₈N₁₈O₁₃S · xC₂H₄O₂ · yH₂O

CAS 번호:

137348-11-9

Molecular Weight:

1347.63 (anhydrous free base basis)

UNSPSC Code:

12352200

PubChem Substance ID:

24899725

NACRES:

NA.32

Beilstein/REAXYS Number:

5153552

Assay:

≥95% (HPLC)

Form:

powder

Quality level:

200

Storage condition:

(Keep container tightly closed in a dry and well-ventilated place.)

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속성

제품 이름

Substance P acetate salt hydrate, ≥95% (HPLC), powder

Quality Level

200

assay

≥95% (HPLC)

form

powder

mol wt

1348 Da by calculation (Average Mass)

storage condition

(Keep container tightly closed in a dry and well-ventilated place.)

color

white

solubility

0.1 M acetic acid: 1 mg/mL

UniProt accession no.

P20366

storage temp.

−20°C

SMILES string

[H]O[H].CC(O)=O.CSCC[C@H](NC(=O)[C@H](CC(C)C)NC(=O)CNC(=O)[C@@H](Cc1ccccc1)NC(=O)[C@H](Cc2ccccc2)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@@H]3CCCN3C(=O)[C@H](CCCCN)NC(=O)[C@@H]4CCCN4C(=O)[C@@H](N)CCCNC(N)=N)C(N)=O

InChI

1S/C63H98N18O13S.C2H4O2.H2O/c1-37(2)33-45(57(89)74-41(53(68)85)27-32-95-3)73-52(84)36-72-54(86)46(34-38-15-6-4-7-16-38)78-58(90)47(35-39-17-8-5-9-18-39)79-56(88)42(23-25-50(66)82)75-55(87)43(24-26-51(67)83)76-59(91)49-22-14-31-81(49)62(94)44(20-10-11-28-64)77-60(92)48-21-13-30-80(48)61(93)40(65)19-12-29-71-63(69)70;1-2(3)4;/h4-9,15-18,37,40-49H,10-14,19-36,64-65H2,1-3H3,(H2,66,82)(H2,67,83)(H2,68,85)(H,72,86)(H,73,84)(H,74,89)(H,75,87)(H,76,91)(H,77,92)(H,78,90)(H,79,88)(H4,69,70,71);1H3,(H,3,4);1H2/t40-,41-,42-,43-,44-,45-,46?,47-,48-,49-;;/m0../s1

InChI key

VHKFRLDSEZYWAC-CIYRQLMPSA-N

Gene Information

human ... TAC1(6863)

설명

General description

Research area: Cell Signaling

Substance P is a member of the tachykinin family of peptides. It is encoded by the tachykinin precursor 1 (TAC1) gene mapped to human chromosome 7q21-q22. Substance P is a small peptide produced by macrophages, lymphocytes, eosinophils, dendritic cells and nerves. It is part of the neurokinin group.

Application

Substance P acetate salt hydrate has been:

used as a neurokinin 1 (NK1) receptor agonist for the activation of spinal nociceptive circuitry in mice
administered in central nucleus (ACE) in rat to study its positive reinforcing effects
used in competition binding assays
used as an inhibitor of myosin light chain kinase in isolated lymphatic vessels from rat

Biochem/physiol Actions

NK-1 agonist; potent vasodilator and hypotensive agent.

NK-1 agonist; potent vasodilator and hypotensive agent; induces salivation; increases capillary permeability; induces mast cell degranulation; putative neurotransmitter in sensory (pain) afferents.

Substance P has proinflammatory effects on epithelial and immune cells. It has been associated with inflammatory diseases related to gastrointestinal and respiratory systems. Substance P modulates contractility of smooth muscles, transport of ions in the epithelium, vascular permeability and immune functions in the gut.

저장 등급

11 - Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

Eyeshields, Gloves, type N95 (US)

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국제 무역 품목 번호

SKU	GTIN
S6883-1.3MG-KC	04061832677866
S6883-25MG	04061832677880
S6883-5MG	04061836959678
S6883-.5MG	04061832677859
S6883-10MG	04061836959661
S6883-1MG	04061826153277