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Merck

P8688

Sigma-Aldrich

(S)-(−)-Propranolol hydrochloride

≥98% (TLC), β1- and β2-aadrenergic receptor blocker, powder

동의어(들):

(S)-1-Isopropylamino-3-(1-naphthyloxy)-2-propanol hydrochloride

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크기 선택

제품정보 (DICE 배송 시 비용 별도)

Linear Formula:
C10H7OCH2CH(OH)CH2NHCH(CH3)2·HCl
CAS 번호:
4199-10-4
Molecular Weight:
295.80
Beilstein:
3574966
EC Number:
224-096-0
MDL number:
MFCD00064547
UNSPSC 코드:
12352200
PubChem Substance ID:
24278657
NACRES:
NA.77

주요 문서

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제품 이름

(S)-(−)-Propranolol hydrochloride, ≥98% (TLC), powder

Quality Level

200

분석

≥98% (TLC)

양식

powder

광학 활성

[α]25/D −25.5°, c = 1.0 in ethanol(lit.)

mp

193-195 °C (lit.)

solubility

ethanol: 10 mg/mL
DMSO: <14.5 mg/mL
H2O: 50 mg/mL
45% (w/v) aq 2-hydroxypropyl-β-cyclodextrin: 8.0 mg/mL

주관자

AstraZeneca

저장 온도

2-8°C

SMILES string

Cl[H].CC(C)NC[C@H](O)COc1cccc2ccccc12

InChI

1S/C16H21NO2.ClH/c1-12(2)17-10-14(18)11-19-16-9-5-7-13-6-3-4-8-15(13)16;/h3-9,12,14,17-18H,10-11H2,1-2H3;1H/t14-;/m0./s1

InChI key

ZMRUPTIKESYGQW-UQKRIMTDSA-N

유전자 정보

human ... ADRB1(153), ADRB2(154), ADRB3(155), HTR1A(3350), HTR1B(3351), HTR1D(3352), HTR1E(3354), HTR1F(3355)

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관련 카테고리

일반 설명

With heat. Aqueous solutions are most stable at pH 3.0 and decompose rapidly at basic pH. Decomposition is accompanied by discoloration of the solution.

애플리케이션

(S)-(−)-Propranolol hydrochloride has been used:
  • as a non-selective β-blocker propranolol to inhibit the actions of epinephrine in mice
  • as a β1- and β2-aadrenergic receptor blocker in rat
  • as a medium supplement to investigate its effect on adipogenesis in hemangioma-derived stem cells (HemSC)

생화학적/생리학적 작용

(S)-(−)-Propranolol hydrochloride is biologically active enantiomer. It acts as β1 receptor antagonist in thalamocortical neurons. (S)-(−)-Propranolol hydrochloride elicits its inhibitory function on the β1 adrenoceptor in trigeminovascular pain pathway and serves as a preventive medicine in migraine.
Active β-adrenoceptor blocking enantiomer, as measured by inhibition of isoprenaline-induced tachycardia; Propranolol is also non-specific 5-HT1A, 5-HT1B and 5-HT1C serotonin receptor antagonist. The stereoselective association of mianserin and propranolol with the 5HT1A, 5HT1B and 5HT1C sites may prove useful in the characterization of these sites

특징 및 장점

This compound is featured on the β-Adrenoceptors page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.
This compound was developed by AstraZeneca. To browse the list of other pharma-developed compounds and Approved Drugs/Drug Candidates, click here.

픽토그램

Exclamation mark
GHS07

신호어

Warning

유해 및 위험 성명서

H302 + H312 + H332

Hazard Classifications

Acute Tox. 4 Dermal - Acute Tox. 4 Inhalation - Acute Tox. 4 Oral

Storage Class Code

11 - Combustible Solids

WGK

WGK 3

Flash Point (°F)

Not applicable

Flash Point (°C)

Not applicable

개인 보호 장비

dust mask type N95 (US), Eyeshields, Gloves

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시험 성적서(COA)

Lot/Batch Number
029M4082V
059M4184V
13190131
087M4043V
13170126

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