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P5515

Prostaglandin E₁

Name: Prostaglandin E<SUB>1</SUB>
Brand: SIGMA

≥98% (HPLC), powder, vasodilator

동의어(들):

(11α,13E,15S)-11,15-Dihydroxy-9-oxoprost-13-enoic acid, Alprostadil, PGE₁

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제품정보 (DICE 배송 시 비용 별도)

실험식(Hill 표기법):

C₂₀H₃₄O₅

CAS 번호:

745-65-3

Molecular Weight:

354.48

PubChem Substance ID:

57654538

eCl@ss:

42020658

UNSPSC Code:

12352211

NACRES:

NA.77

EC Number:

212-017-2

MDL number:

MFCD00077860

Beilstein/REAXYS Number:

5294062

Assay:

≥98% (HPLC)

Form:

(powder to crystals)

Quality level:

200

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속성

제품 이름

Prostaglandin E₁, ≥98% (HPLC), synthetic

biological source

synthetic

Quality Level

200

assay

≥98% (HPLC)

form

(powder to crystals)

solubility

ethanol: 5 mg/mL

storage temp.

−20°C

SMILES string

O=C1[C@H](CCCCCCC(O)=O)[C@@H](/C=C/[C@H](CCCCC)O)[C@H](O)C1

InChI

1S/C20H34O5/c1-2-3-6-9-15(21)12-13-17-16(18(22)14-19(17)23)10-7-4-5-8-11-20(24)25/h12-13,15-17,19,21,23H,2-11,14H2,1H3,(H,24,25)/b13-12+/t15-,16+,17+,19+/m0/s1

InChI key

GMVPRGQOIOIIMI-DWKJAMRDSA-N

Gene Information

human ... PTGER1(5731), PTGER2(5732), PTGIR(5739)
mouse ... Ptger1(19216), Ptger2(19217), Ptger3(19218), Ptger4(19219)

설명

Application

Prostaglandin E1 has been used:

as a platelet inhibitor to analyse its effect on autophagy
in platelet adhesion assay
to investigate its effect on cAMP production in thyroid glands of normal and growth-retarded mouse in vitro.

Biochem/physiol Actions

Prostaglandin E1 (PGE1) is a hormone synthesized from dihomo-γ-linolenic acid (DGLA) by the action of enzyme prostaglandin synthase. It is a vasodilator and activates adenylate cyclase. It is majorly present in human semen and is a potent platelet aggregation inhibitor. PGE1 infusions is effective in treating limb ischemia and peripheral vascular disease. It is unstable and is hydrolyzed to PGA1 in the lungs. Nanoparticle encapsulation of PGE1 is essential for its delivery at the vascular injury site. It elicits vasodilator effects on the retinal artery and vein in central retinal artery occlusion (CRAO). PGE1 and its synthetic analog misoprostol interact with E-prostanoid receptor 4 (EP4) and elicits protection in chronic myelogenous leukemia (CML).