N7758
Naloxone hydrochloride dihydrate
≥98% (TLC and titration), μ, κ, δ, and σ opioid receptor antagonist, powder
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제품정보 (DICE 배송 시 비용 별도)
실험식(Hill 표기법):
C19H21NO4 · HCl · 2H2O
CAS 번호:
Molecular Weight:
399.87
NACRES:
NA.77
PubChem Substance ID:
UNSPSC Code:
12352200
MDL number:
Beilstein/REAXYS Number:
6260807
제품 이름
Naloxone hydrochloride dihydrate, ≥98% (TLC and titration), powder
Quality Level
assay
≥98% (TLC and titration)
form
powder
optical activity
[α]25/D −178.6°, c = 2.5 in H2O(lit.)
color
white to off-white
solubility
ethanol: 3.3 mg/mL, H2O: 50 mg/mL
storage temp.
2-8°C
SMILES string
O.O.Cl.Oc1ccc2C[C@H]3N(CC[C@@]45[C@@H](Oc1c24)C(=O)CC[C@@]35O)CC=C
InChI
1S/C19H21NO4.ClH.2H2O/c1-2-8-20-9-7-18-15-11-3-4-12(21)16(15)24-17(18)13(22)5-6-19(18,23)14(20)10-11;;;/h2-4,14,17,21,23H,1,5-10H2;1H;2*1H2/t14-,17+,18+,19-;;;/m1.../s1
InChI key
TXMZWEASFRBVKY-IOQDSZRYSA-N
Gene Information
human ... OPRD1(4985), OPRK1(4986), OPRM1(4988), OPRS1(10280)
Application
Naloxone hydrochloride dihydrate has been used in:
- isotonic saline and injected subcutaneously into experimental rats to study its involvement with withdrawal syndrome in morphine-dependent rats
- as opioid receptor antagonist to examine the role of the endogenous opioid system in infantile amnesia for contextual fear
- as a reference neutral antagonist to define the maximum effect (Emax) of the system
Biochem/physiol Actions
Competitive antagonist for μ, κ, δ, and σ opioid receptors; blocks the action of σ-agonists at opioid sites. Naloxone′s antagonistic effect last for about 45 min and thus, requires repeated dosage. It results in critical side effects such as pulmonary edema.
Features and Benefits
This compound is featured on the Opioid Receptors page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.
Disclaimer
Light sensitive.
signalword
Warning
hcodes
Hazard Classifications
Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3
target_organs
Respiratory system
저장 등급
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
ppe
dust mask type N95 (US), Eyeshields, Gloves
Jee Hyun Kim et al.
Learning & memory (Cold Spring Harbor, N.Y.), 16(3), 161-166 (2009-02-19)
Several recent studies report that neurotransmitters that are critically involved in extinction in adult rats are not important for extinction in young rats. Specifically, pretest injection of the gamma-aminobutryic acid (GABA) receptor inverse agonist FG7142 has no effect on extinction
Pharmacologic Profile of Naloxegol, a Peripherally Acting mu-Opioid Receptor Antagonist, for the Treatment of Opioid-Induced Constipation
Floettmann E, et al.
Journal of Pharmacology and Experimental Therapeutics, 361(2), 280-291 (2017)
Opiate withdrawal-induced place aversion lasts for up to 16 weeks
Stinus L, et al.
Psychopharmacology, 149(2), 115-120 (2000)
국제 무역 품목 번호
| SKU | GTIN |
|---|---|
| N7758-250MG | 04061834118176 |
| N7758-5G | 04061832557588 |
| N7758-1G | 04061834118169 |