N7389
3-Nitro-L-tyrosine
Oxidant, crystalline
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제품정보 (DICE 배송 시 비용 별도)
Linear Formula:
O2NC6H3-4-(OH)CH2CH(NH2)CO2H
CAS 번호:
Molecular Weight:
226.19
NACRES:
NA.32
PubChem Substance ID:
eCl@ss:
32160406
UNSPSC Code:
12352200
EC Number:
210-688-6
MDL number:
Beilstein/REAXYS Number:
2813157
Form:
crystalline
Quality level:
제품 이름
3-Nitro-L-tyrosine, crystalline
form
crystalline
Quality Level
mp
233-235 °C (dec.) (lit.)
SMILES string
N[C@@H](Cc1ccc(O)c(c1)[N+]([O-])=O)C(O)=O
InChI
1S/C9H10N2O5/c10-6(9(13)14)3-5-1-2-8(12)7(4-5)11(15)16/h1-2,4,6,12H,3,10H2,(H,13,14)/t6-/m0/s1
InChI key
FBTSQILOGYXGMD-LURJTMIESA-N
Application
3-Nitro-L-tyrosine has been used in:
- western blot analysis to quantify the nitrotyrosine levels in mice tissue protein
- Murashige–Skoog medium to treat wild type and mitogen-activated protein kinase 6 (mpk6)-2 mutant seedlings for inferring the connection between nitric oxide (NO) and MPK6 functions in the regulation of mitotic microtubule organization
- immunocytochemistry
Biochem/physiol Actions
3-Nitro-L-tyrosine is an oxidant and cytotoxic agent. 3-Nitrotyrosine serves as a biological marker of proteins modified by nitrogen-free radical species in systemic autoimmunogenic conditions. It is a marker for oxidative damage mediated by peroxynitrite. Nitrotyrosine is associated with VEGF-C expression and lymph node metastasis in breast cancer. 3-Nitrotyrosine is produced due to oxidative/nitrosative stress-mediated chemical modifications such as nitration of proteins, which is observed in lung carcinogenesis.
저장 등급
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
ppe
Eyeshields, Gloves, type N95 (US)
Jake Jianjun Wen et al.
PLoS pathogens, 14(5), e1007065-e1007065 (2018-06-01)
Chagasic cardiomyopathy is caused by Trypanosoma cruzi infection. Poly(ADP-ribose) polymerase 1 (PARP1) is known for its function in nuclear DNA repair. In this study, we have employed genetic deletion and chemical inhibition approaches to determine the role of PARP1 in
Eman Ahmed Alaa El-Din et al.
Environmental science and pollution research international, 26(21), 21556-21564 (2019-05-28)
The evaluation of the toxicological effects of titanium dioxide nanoparticles (TiO2NPs) is increasingly important due to their growing occupational and industrial use. Curcumin is a yellow curry spice with a long history of use in herbal medicine and has numerous
Tzu-Hao Li et al.
Scientific reports, 6, 39405-39405 (2016-12-23)
Thalidomide can modulate the TNFα-NFκB and iNOS pathway, which involve in the pathogenesis of hepatopulmonary syndrome (HPS) and muscle wasting in cirrhosis. In bile duct ligated-cirrhotic rats, the increased circulating CD16+ (inflammatory) monocytes and its intracellular TNFα, NFκB, monocyte chemotactic
국제 무역 품목 번호
| SKU | GTIN |
|---|---|
| N7389-25G | 04061833631157 |
| N7389-10G | 04061833631140 |
| N7389-5G | 04061834118008 |