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N4267

Neurokinin A

Name: Neurokinin A
Brand: SIGMA

≥97% (HPLC), tachykinin peptide, powder

동의어(들):

α-Neurokinin, Neuromedin L, Substance K

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제품정보 (DICE 배송 시 비용 별도)

Linear Formula:

C₅₀H₇₉N₁₃O₁₅S

CAS 번호:

86933-74-6

Molecular Weight:

1133.32

UNSPSC Code:

51111800

PubChem Substance ID:

24897700

NACRES:

NA.32

MDL number:

MFCD00167560

Assay:

≥97% (HPLC)

Form:

powder

Quality level:

200

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속성

제품 이름

Neurokinin A, ≥97% (HPLC)

Quality Level

200

assay

≥97% (HPLC)

form

powder

composition

Peptide content, ≥70%

UniProt accession no.

P20366

storage temp.

−20°C

SMILES string

CSCCC(NC(=O)C(CC(C)C)NC(=O)CNC(=O)C(NC(=O)C(Cc1ccccc1)NC(=O)C(CO)NC(=O)C(CC(O)=O)NC(=O)C(NC(=O)C(CCCCN)NC(=O)C(N)Cc2cnc[nH]2)C(C)O)C(C)C)C(N)=O

InChI

1S/C50H80N14O14S/c1-26(2)18-34(45(73)58-32(42(53)70)15-17-79-6)57-38(67)23-55-49(77)40(27(3)4)63-47(75)35(19-29-12-8-7-9-13-29)60-48(76)37(24-65)62-46(74)36(21-39(68)69)61-50(78)41(28(5)66)64-44(72)33(14-10-11-16-51)59-43(71)31(52)20-30-22-54-25-56-30/h7-9,12-13,22,25-28,31-37,40-41,65-66H,10-11,14-21,23-24,51-52H2,1-6H3,(H2,53,70)(H,54,56)(H,55,77)(H,57,67)(H,58,73)(H,59,71)(H,60,76)(H,61,78)(H,62,74)(H,63,75)(H,64,72)(H,68,69)

InChI key

HEAUFJZALFKPBA-UHFFFAOYSA-N

Gene Information

human ... TAC1(6863)

설명

General description

Neurokinin A is an 11 amino acid peptide. It is a member of tachykinin family, which includes neurokinin A, neurokinin B, neuropeptide K, neuropeptide Y and hemokinin-1. The gene encoding neurokinin A is localized on human chromosome 7q21.3.

Biochem/physiol Actions

Neurokinin A improves the multiplication and paracrine ability of stem cells acquired from adipose in vitro. It participates in the movement of several organ tracts, triggers glandular secretion and controls autonomic reflexes. Neurokinin A plays an important role in neuroimmune and systemic autoimmune/inflammatory conditions like multiple sclerosis (MS), rheumatoid arthritis, inflammatory bowel disease and also in infections and cancer.

Other Notes

Lyophilized from 0.1% TFA in H2O

저장 등급

11 - Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

Eyeshields, Gloves, type N95 (US)

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문서 라이브러리 방문

Substance P enhances proliferation and paracrine potential of adipose-derived stem cells in vitro.

Kim S

Biochemical and Biophysical Research Communications (2017)

Tachykinin receptor subtypes in the isolated guinea pig heart and their role in mediating responses to neurokinin A.

Y Chang et al.

The Journal of pharmacology and experimental therapeutics, 294(1), 147-154 (2000-06-28)

Selective tachykinin agonists were used to identify cardiac and coronary responses mediated by specific tachykinin receptor subtypes in isolated, perfused guinea pig hearts. Receptor desensitization with selective agonists and blockade with selective antagonists were used to determine the role of

Reciprocal Regulation of Substance P and IL-12/IL-23 and the Associated Cytokines, IFN?/IL-17: A Perspective on the Relevance of This Interaction to Multiple Sclerosis

Janek V

Journal of Neuroimmune Pharmacology (2015)

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국제 무역 품목 번호

SKU	GTIN
N4267-.5MG	04061832677361
N4267-1MG	04061834116530