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M7319

ML 10302

Name: ML 10302
Brand: SIGMA

≥98%, solid

동의어(들):

2-Piperidinoethyl 4-amino-5-chloro-2-methoxybenzoate

조직 및 계약 가격을 보려면 로그인를 클릭합니다.

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제품정보 (DICE 배송 시 비용 별도)

실험식(Hill 표기법):

C₁₅H₂₁ClN₂O₃

CAS 번호:

148868-55-7

Molecular Weight:

312.79

NACRES:

NA.77

PubChem Substance ID:

24724541

UNSPSC Code:

12352202

MDL number:

MFCD00931669

Assay:

≥98%

Form:

solid

Quality level:

100

기술 서비스

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도움 문의

속성

Quality Level

100

assay

≥98%

form

solid

color

white to off-white

solubility

DMSO: >20 mg/mL, H₂O: insoluble

storage temp.

2-8°C

SMILES string

COc1cc(N)c(Cl)cc1C(=O)OCCN2CCCCC2

InChI

1S/C15H21ClN2O3/c1-20-14-10-13(17)12(16)9-11(14)15(19)21-8-7-18-5-3-2-4-6-18/h9-10H,2-8,17H2,1H3

InChI key

RVFIAQAAZUEPPE-UHFFFAOYSA-N

Gene Information

rat ... Htr3a(79246), Htr4(25324)

설명

Biochem/physiol Actions

Potent, selective 5-HT₄ serotonin receptor agonist

저장 등급

11 - Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

Eyeshields, Gloves, type N95 (US)

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시험 성적서(COA)

Lot/Batch Number

068K4617

105K4606

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문서 라이브러리 방문

New esters of 4-amino-5-chloro-2-methoxybenzoic acid as potent agonists and antagonists for 5-HT4 receptors.

D Yang et al.

Journal of medicinal chemistry, 40(4), 608-621 (1997-02-14)

A number of benzoates derived from 4-amino-5-chloro-2-methoxybenzoic acid and substituted 1-piperidineethanol were synthesized and found to be potent 5-HT4 receptor agonists in the electrically-stimulated myenteric plexus and longitudinal muscle of the guinea pig ileum and the rat esophagus muscle. Monosubstitution

Design and synthesis of specific probes for human 5-HT4 receptor dimerization studies.

Jean-Louis Soulier et al.

Journal of medicinal chemistry, 48(20), 6220-6228 (2005-09-30)

Recently, human 5-HT4 receptors have been demonstrated to form constitutive dimers in living cells. To evaluate the role of dimerization on the 5-HT4 receptor function, we investigated the conception and the synthesis of bivalent molecules able to influence the dimerization

Intestinal motor stimulation by the 5-HT4 receptor agonist ML10302: differential involvement of tachykininergic pathways in the canine small bowel and colon.

F De Ponti et al.

Neurogastroenterology and motility : the official journal of the European Gastrointestinal Motility Society, 13(6), 543-553 (2002-03-21)

5-Hydroxytryptamine (5-HT)4 receptor agonists stimulate gut motility through cholinergic pathways, although there are data suggesting that noncholinergic (tachykininergic) excitatory pathways may also be involved. Differences may exist between the small bowel and colon. Our aims were: (i) to compare the

국제 무역 품목 번호

SKU	GTIN
M7319-50MG	04061832272436
M7319-10MG	04061832083247