M1547
Metronidazole
BioXtra
동의어(들):
2-Methyl-5-nitroimidazole-1-ethanol
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제품정보 (DICE 배송 시 비용 별도)
실험식(Hill 표기법):
C6H9N3O3
CAS 번호:
Molecular Weight:
171.15
UNSPSC Code:
51282808
NACRES:
NA.76
PubChem Substance ID:
EC Number:
207-136-1
Beilstein/REAXYS Number:
611683
MDL number:
product line
BioXtra
impurities
≤0.2% Total Impurities
ign. residue
≤0.1%
color
white to light yellow
mp
159-161 °C (lit.)
solubility
acetic acid: 0.1 M, clear, colorless to yellow
anion traces
chloride (Cl-): ≤0.05%, sulfate (SO42-): ≤0.05%
cation traces
Al: ≤0.0005%, Ca: ≤0.005%, Cu: ≤0.0005%, Fe: ≤0.0005%, K: ≤0.005%, Mg: ≤0.0005%, Na: ≤0.01%, Pb: ≤0.001%, Zn: ≤0.0005%
antibiotic activity spectrum
Gram-negative bacteria, parasites
mode of action
DNA synthesis | interferes
storage temp.
2-8°C
SMILES string
CC1=NC=C([N+]([O-])=O)N1CCO
InChI
1S/C6H9N3O3/c1-5-7-4-6(9(11)12)8(5)2-3-10/h4,10H,2-3H2,1H3
InChI key
VAOCPAMSLUNLGC-UHFFFAOYSA-N
General description
Chemical structure: imidazole
Application
Metronidazole is used to study DNA damage and repair and has been found to induce the gene transfer agent VSH-1 in Brachyspira hyodysenteriae. It is commonly used for treatment of periodontitis and is used in bioavailability studies.
Biochem/physiol Actions
Metronidazole is a prodrug and is selective for anaerobic bacteria due to their ability to intracellularly reduce metronidazole to its active form. Reduced metronidazole covalently binds to DNA which disrupts its helical structure, induces DNA strand breaks and inhibits bacterial nucleic acid synthesis. Bacterial cell death results.
signalword
Danger
hcodes
Hazard Classifications
Carc. 1B - Muta. 1B - STOT RE 2
저장 등급
6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects
wgk
WGK 3
ppe
dust mask type N95 (US), Eyeshields, Gloves
Tal Frolinger et al.
Scientific reports, 9(1), 3546-3546 (2019-03-07)
Dietary polyphenols promote memory in models of sleep deprivation (SD), stress, and neurodegeneration. The biological properties of dietary polyphenols greatly depend upon the bioavailability of their phenolic metabolites derivatives, which are modulated by gut microbiota. We recently demonstrated that supplementation
Sonja Löfmark et al.
Clinical infectious diseases : an official publication of the Infectious Diseases Society of America, 50 Suppl 1, S16-S23 (2010-01-14)
Metronidazole has been used for the treatment of infections for >45 years and is still successfully used for the treatment of trichomoniasis, amoebiasis, and giardiasis. Anaerobic bacterial infections caused by Bacteroides species, fusobacteria, and clostridia respond favorably to metronidazole therapy.
D Nyasha Chagwedera et al.
Cell metabolism, 30(2), 364-373 (2019-05-28)
Microbial dysbiosis and inflammation are implicated in diet-induced obesity and insulin resistance. However, it is not known whether crosstalk between immunity and microbiota also regulates metabolic homeostasis in healthy animals. Here, we report that genetic deletion of tuberous sclerosis 1
국제 무역 품목 번호
| SKU | GTIN |
|---|---|
| M1547-25G | 04061834040880 |
| M1547-5G | 04061834040897 |