L5793
Leupeptin
powder, ≥95% (HPLC)
동의어(들):
Leupeptin hemisulfate salt, Acetyl-Leu-Leu-Arg-al, N-Acetyl-L-leucyl-L-leucyl-L-argininal hemisulfate salt
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제품정보 (DICE 배송 시 비용 별도)
Linear Formula:
C20H38N6O4 · 1/2H2SO4
CAS 번호:
Molecular Weight:
475.59
UNSPSC Code:
12352202
PubChem Substance ID:
NACRES:
NA.77
MDL number:
제품 이름
Leupeptin, BioUltra, microbial, ≥95% (HPLC)
biological source
microbial
Quality Level
product line
BioUltra
assay
≥95% (HPLC)
form
powder
solubility
H2O: 50 mg/mL
storage temp.
−20°C
SMILES string
OS(O)(=O)=O.CC(C)C[C@H](NC(C)=O)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCNC(N)=N)C=O.CC(C)C[C@H](NC(C)=O)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCNC(N)=N)C=O
InChI
1S/2C20H38N6O4.H2O4S/c2*1-12(2)9-16(24-14(5)28)19(30)26-17(10-13(3)4)18(29)25-15(11-27)7-6-8-23-20(21)22;1-5(2,3)4/h2*11-13,15-17H,6-10H2,1-5H3,(H,24,28)(H,25,29)(H,26,30)(H4,21,22,23);(H2,1,2,3,4)/t2*15-,16-,17-;/m00./s1
InChI key
CIPMKIHUGVGQTG-VFFZMTJFSA-N
Biochem/physiol Actions
Inhibitor of serine and cysteine proteases. Inhibits plasmin, trypsin, papain, calpain, and cathepsin B. Does not inhibit pepsin, cathepsins A and D, thrombin, or α-chymotrypsin. Effective concentration 10-100 μM.
Inhibitor of serine and cysteine proteases. Inhibits plasmin, trypsin, papain, calpain, and cathepsin B. Does not inhibit pepsin, cathepsins A and D, thrombin, or α-chymotrypsin. Effective concentration 10-100 μM. There have been numerous studies using leupeptin to protect against hearing loss caused by acoustic overstimulation or the ototoxic antibiotic gentamicin. (Loss of cochlear hair cells is believed to be mediated by calpain.)
Analysis Note
Leupeptin gives multiple peaks on HPLC because of the formation of tautomeric isomers in solution. Majority of contaminating peptide is racemized leupeptin.
저장 등급
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
ppe
Eyeshields, Gloves, type N95 (US)
관련 콘텐츠
Massimo Ganassi et al.
Molecular cell, 63(5), 796-810 (2016-08-30)
Stress granules (SGs) are ribonucleoprotein complexes induced by stress. They sequester mRNAs and disassemble when the stress subsides, allowing translation restoration. In amyotrophic lateral sclerosis (ALS), aberrant SGs cannot disassemble and therefore accumulate and are degraded by autophagy. However, the
Abigail Buchwalter et al.
eLife, 8 (2019-10-11)
The inner nuclear membrane (INM) is a subdomain of the endoplasmic reticulum (ER) that is gated by the nuclear pore complex. It is unknown whether proteins of the INM and ER are degraded through shared or distinct pathways in mammalian
Qinggong Wang et al.
Nature communications, 13(1), 454-454 (2022-01-26)
Melatonin receptors (MT1 and MT2 in humans) are family A G protein-coupled receptors that respond to the neurohormone melatonin to regulate circadian rhythm and sleep. Numerous efforts have been made to develop drugs targeting melatonin receptors for the treatment of
국제 무역 품목 번호
| SKU | GTIN |
|---|---|
| L5793-100MG | 04061833219379 |
| L5793-5MG | 04061833958469 |
| L5793-25MG | 04061833219386 |