H9772
5-Hydroxy-L-tryptophan
≥98% (TLC), suitable for HPLC
동의어(들):
L-2-Amino-3-(5-hydroxyindolyl)propionic acid, L-5-HTP
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크기 선택
제품정보 (DICE 배송 시 비용 별도)
실험식(Hill 표기법):
C11H12N2O3
CAS 번호:
Molecular Weight:
220.22
EC Number:
MDL number:
UNSPSC 코드:
12352209
eCl@ss:
32160406
PubChem Substance ID:
NACRES:
NA.77
제품 이름
5-Hydroxy-L-tryptophan, powder
분석
≥98% (TLC)
Quality Level
양식
powder
기술
HPLC: suitable
색상
white to faint beige
저장 온도
2-8°C
SMILES string
N[C@@H](Cc1c[nH]c2ccc(O)cc12)C(O)=O
InChI
1S/C11H12N2O3/c12-9(11(15)16)3-6-5-13-10-2-1-7(14)4-8(6)10/h1-2,4-5,9,13-14H,3,12H2,(H,15,16)/t9-/m0/s1
InChI key
LDCYZAJDBXYCGN-VIFPVBQESA-N
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일반 설명
5-Hydroxy-L-tryptophan (5-HTP) is naturally found in Griffonia simplicifolia.
애플리케이션
5-Hydroxy-L-tryptophan has been used:
- to inject experimental mice for serotonin detection
- as a precursor of 5-hydroxytryptamine and injected in pregnant mice and neonatal rats for vital neutral red staining of lung slices
- as a standard in citrate-acetate buffer for its use in high performance liquid chromatography (HPLC) analysis
생화학적/생리학적 작용
Hydroxylation of L-tryptophan occurs in the brain during serotonin synthesis. This is a step that controls the production of serotonin and also yields 5-hydroxy-l-tryptophan (5-HTP) as a metabolite. Thus, consumption 5-HTP, increases the serotonin level, which might result in depression, lack of sleep and severe headache.
Immediate precursor of serotonin; L-aromatic amino acid decarboxylase substrate.
면책조항
Light sensitive
신호어
Danger
유해 및 위험 성명서
Hazard Classifications
Acute Tox. 3 Oral
Storage Class Code
6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects
WGK
WGK 1
Flash Point (°F)
Not applicable
Flash Point (°C)
Not applicable
개인 보호 장비
dust mask type N95 (US), Eyeshields, Faceshields, Gloves
Endocrine taste cells
Kokrashvili Z, et al.
The British Journal of Nutrition, 111(S1), S23-S29 (2014)
M G Marrero et al.
Scientific reports, 10(1), 9712-9712 (2020-06-18)
Dairy calves are born with a naïve immune system, making the pre-weaning phase a critical window for immune development. In the U.S., 40-60% of dairy farms feed milk replacer to pre-weaned calves, which are devoid of bioactive factors with immunological
Andrew N Bubak et al.
PloS one, 14(1), e0203980-e0203980 (2019-01-30)
Despite the conserved function of aggression across taxa in obtaining critical resources such as food and mates, serotonin's (5-HT) modulatory role on aggressive behavior appears to be largely inhibitory for vertebrates but stimulatory for invertebrates. However, critical gaps exist in
Enhanced synthesis of 5-hydroxy-l-tryptophan through tetrahydropterin regeneration
Hara R and Kino K
AMB Express, 3(1), 70-70 (2013)
Ke Chen et al.
Experimental brain research, 237(11), 2925-2938 (2019-09-09)
It was shown in previous studies that endurance training enhanced excitability of rat spinal motoneurons. However, the influence of the training on the spinal interneurons remains unclear. In this study, we investigated the training effects on spinal interneurons in dorsal
문서
Serotonin is stored in cells and metabolized by MAO, influencing CNS, GI, and platelet functions.
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