H2138
Hexamethonium chloride
solid (hygroscopic)
동의어(들):
Hexamethonium dichloride, N,N,N,N′,N′,N′-Hexamethyl-1,6-hexanediaminium dichloride, N,N,N,N′,N′,N′-Hexamethylhexamethylenediammonium dichloride
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크기 선택
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제품정보 (DICE 배송 시 비용 별도)
Linear Formula:
(CH3)3N(Cl)(CH2)6N(Cl)(CH3)3
CAS 번호:
Molecular Weight:
273.29
UNSPSC Code:
12352200
NACRES:
NA.77
PubChem Substance ID:
EC Number:
200-465-1
Beilstein/REAXYS Number:
3714806
MDL number:
Form:
solid (hygroscopic)
form
solid (hygroscopic)
color
white
solubility
H2O: soluble, ethanol: soluble
SMILES string
[Cl-].[Cl-].C[N+](C)(C)CCCCCC[N+](C)(C)C
InChI
1S/C12H30N2.2ClH/c1-13(2,3)11-9-7-8-10-12-14(4,5)6;;/h7-12H2,1-6H3;2*1H/q+2;;/p-2
InChI key
PYIHTIJNCRKDBV-UHFFFAOYSA-L
Gene Information
General description
Nicotinic acetylcholine receptor (nAChR) forms a ligand-gated ion channel made up of four different subunits. Each subunit contains an extracellular amino-terminal domain (hydrophilic) and carboxylic terminal domain and four transmembrane domains. nAChR is an allosteric and transmembrane protein localized to the neuromuscular junction.
Application
Hexamethonium chloride has been used to block the responses of nicotinic receptors towards it agonists. It has also been used to study the mechanosensitivity of viscerofugal neurons.
Biochem/physiol Actions
Hexamethonium chloride preferentially blocks nicotinic receptors at autonomic ganglia, crosses blood-brain barrier only at high doses. Nicotinic acetylcholine receptor (nAChR) is responsible for cognitive functions. Blocking this receptor results in cognitive impairment. nAChR antagonist is used to study the effect of loss of receptor function. Hexamethonium has a peripheral action over blocking the nAChR.
저장 등급
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
ppe
Eyeshields, Gloves, type N95 (US)
Animal Models of Cognitive Impairment, 381-394 (2006)
Lateral Diffusion, Function and Expression of the Slow Channel Congenital Myasthenia Syndrome alphaC418W Nicotinic Receptor Mutation with Changes in Lipid Raft Components
Oyola-Cintron J, et al.
The Journal of Biological Chemistry, jbc-M115 (2015)
Julia Yuen Hang Liu et al.
American journal of physiology. Gastrointestinal and liver physiology, 319(1), G97-G107 (2020-06-02)
The effect of acetylcholine (ACh) on pacemaking and spontaneous contractions in the gastrointestinal tract is not well characterized. The current study aims to profile the effect of several muscarinic and nicotinic receptor agonists and antagonists on pacemaker potentials in the
국제 무역 품목 번호
| SKU | GTIN |
|---|---|
| H2138-25G | 04061833791844 |
| H2138-5G | 04061833791851 |