H0627
6-Hydroxymelatonin
antioxidant
동의어(들):
3-(N-Acetylaminoethyl)-6-hydroxy-5-methoxyindole
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제품정보 (DICE 배송 시 비용 별도)
실험식(Hill 표기법):
C13H16N2O3
CAS 번호:
Molecular Weight:
248.28
UNSPSC Code:
41116107
PubChem Substance ID:
NACRES:
NA.77
MDL number:
Quality level:
제품 이름
6-Hydroxymelatonin,
solubility
alcohol: soluble
Quality Level
SMILES string
COc1cc2c(CCNC(C)=O)c[nH]c2cc1O
InChI
1S/C13H16N2O3/c1-8(16)14-4-3-9-7-15-11-6-12(17)13(18-2)5-10(9)11/h5-7,15,17H,3-4H2,1-2H3,(H,14,16)
InChI key
OMYMRCXOJJZYKE-UHFFFAOYSA-N
Gene Information
human ... MTNR1A(4543), MTNR1B(4544)
General description
6-Hydroxymelatonin (6-OHM) is a melatonin metabolite. It is produced in the liver by the action of cytochrome P450 enzyme as well as by photodegradation of melatonin. In the central nervous system, it exists as a sulfated form. 6-OHM is a partial melatonin receptor MT2 agonist.
Application
6-Hydroxymelatonin has been used as a melatonin derivative to test its protective effects in ultra violet B (UVB)-induced oxidative stress melanocytes and keratinocytes.
Biochem/physiol Actions
6-Hydroxymelatonin (6-OHM) is an antioxidant with a free radical scavenging role. Like melatonin, it reduces the impact of UVB-induced oxidative stress in melanocytes. It also aids protection during iron (Fe2+)-induced neurotoxicity. 6-OHM effectively reduces lipid peroxidation and superoxide anion production induced by potassium cyanide (KCN).
signalword
Warning
hcodes
Hazard Classifications
Acute Tox. 4 Oral - Carc. 2
저장 등급
11 - Combustible Solids
wgk
WGK 3
ppe
Eyeshields, Gloves, type P3 (EN 143) respirator cartridges
Deepa S Maharaj et al.
Journal of neurochemistry, 96(1), 78-81 (2005-11-23)
Oxidative damage of biological macromolecules is a hallmark of most neurodegenerative disorders such as Alzheimer, Parkinson and diffuse Lewy body diseases. Another important phenomenon involved in these disorders is the alteration of iron homeostasis, with an increase in iron levels.
Xuwan Liu et al.
American journal of physiology. Heart and circulatory physiology, 283(1), H254-H263 (2002-06-14)
The present study was designed to explore the protective effects of melatonin and its analogs, 6-hydroxymelatonin and 8-methoxy-2-propionamidotetralin, on the survival of doxorubicin-treated mice and on doxorubicin-induced cardiac dysfunction, ultrastructural alterations, and apoptosis in mouse hearts. Whereas 60% of the
Katsuhisa Sakano et al.
Biochemical pharmacology, 68(9), 1869-1878 (2004-09-29)
Melatonin, an indolic pineal hormone, is produced primarily at night in mammals and is important in controlling biological rhythms. Although melatonin is known to be effective as a free radical scavenger and has an anti-cancer effect, carcinogenic properties have also
국제 무역 품목 번호
| SKU | GTIN |
|---|---|
| H0627-50MG | 04061832556680 |