G1269
Gly-Arg-Gly-Asp-Ser-Pro-Lys
≥97% (HPLC)
동의어(들):
GRGDSPK
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제품정보 (DICE 배송 시 비용 별도)
실험식(Hill 표기법):
C28H49N11O11
CAS 번호:
Molecular Weight:
715.76
MDL number:
UNSPSC Code:
12352209
PubChem Substance ID:
NACRES:
NA.32
Form:
powder
Assay:
≥97% (HPLC)
Biological source:
human
biological source
human
Quality Level
assay
≥97% (HPLC)
form
powder
technique(s)
blocking: suitable, ligand binding assay: suitable
storage temp.
−20°C
SMILES string
NCCCC[C@H](NC(=O)[C@@H]1CCCN1C(=O)[C@H](CO)NC(=O)[C@H](CC(O)=O)NC(=O)CNC(=O)[C@H](CCCNC(N)=N)NC(=O)CN)C(O)=O
InChI
1S/C28H49N11O11/c29-8-2-1-5-16(27(49)50)37-25(47)19-7-4-10-39(19)26(48)18(14-40)38-24(46)17(11-22(43)44)36-21(42)13-34-23(45)15(35-20(41)12-30)6-3-9-33-28(31)32/h15-19,40H,1-14,29-30H2,(H,34,45)(H,35,41)(H,36,42)(H,37,47)(H,38,46)(H,43,44)(H,49,50)(H4,31,32,33)/t15-,16-,17-,18-,19-/m0/s1
InChI key
ZRVZOBGMZWVJOS-VMXHOPILSA-N
Gene Information
human ... ITGA2B(3674), ITGAV(3685)
General description
Gly-Arg-Gly-Asp-Ser-Pro-Lys is a RGD peptide. Naturally occurring RGD peptides, present in the ECM (extracellalar matrix) proteins, are involved in facilitating integrin-mediated cell adhesion to matrix proteins. RGD peptide is present as repeats in cell-adhesion protein, such as fibronectin and vitronectin. This tripeptide is recognized by cells by specific integrins (e.g. β1 , β3 , and β5 subunits), present on the cell surface and associated with the actin filament via the FA (focal adhesion)-complex.
Application
Gly-Arg-Gly-Asp-Ser-Pro-Lys (RGD peptide) has been used-
- as a blocking peptide to inhibit integrin-fibronectin binding
- in adhesion assay performed on porcine trophectoderm to study the influence of TGFβ (transforming growth factor) on cell adhesion
- for incubation of MC3T3-E1 osteoblast cells to determine its effect on cell adhesion measured by AFM (atomic force microscopy)
- for the preparation of RGD.Flt23k.NR nanoparticles
- to determine the involvement of RGD-integrin bonding in cell adhesion process
Biochem/physiol Actions
Fibronectin analog that binds to integrins.
저장 등급
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
ppe
Eyeshields, Gloves, type N95 (US)
Yang Kyung Cho et al.
Investigative ophthalmology & visual science, 53(4), 2328-2336 (2012-03-20)
To determine if nanoparticles delivering plasmids expressing Flt23k (an anti-VEGF intraceptor) can enhance murine cornea transplant survival and whether their effect is synergistic with steroid therapy. Biodegradable PLGA Flt23k loaded or blank nanoparticles were prepared using the emulsion solvent evaporation
Kazuyuki Onodera et al.
European journal of cell biology, 84(1), 45-58 (2005-02-24)
Biomechanical forces are major epigenetic factors that determine the form and differentiation of skeletal tissues, and may be transduced through cell adhesion to the intracellular biochemical signaling pathway. To test the hypothesis that stepwise stretching is translated to molecular signals
Lily Y Koo et al.
Journal of cell science, 115(Pt 7), 1423-1433 (2002-03-16)
Integrin-mediated cell adhesion is central to cell survival, differentiation and motility. Many cell responses induced by integrins require both receptor occupancy and receptor aggregation, and appear to be regulated by both biochemical and biophysical means. Multidomain extracellular matrix molecules may
국제 무역 품목 번호
| SKU | GTIN |
|---|---|
| G1269-1MG | 04061826738627 |