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F9677

Felodipine

Name: Felodipine
Brand: SIGMA

L-type calcium channel blocker, solid

동의어(들):

4-(2,3-Dichlorophenyl)-1,4-dihydro-2,6-dimethyl-3,5-pyridinecarboxylic acid ethyl methyl ester, Plendil

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제품정보 (DICE 배송 시 비용 별도)

실험식(Hill 표기법):

C₁₈H₁₉NO₄Cl₂

CAS 번호:

72509-76-3

Molecular Weight:

384.25

UNSPSC Code:

12352200

PubChem Substance ID:

24278449

NACRES:

NA.77

MDL number:

MFCD00868316

Form:

solid

Quality level:

200

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속성

제품 이름

Felodipine, solid

form

solid

Quality Level

200

solubility

DMSO: 20 mg/mL, H₂O: insoluble

originator

AstraZeneca

SMILES string

CCOC(=O)C1=C(C)NC(C)=C(C1c2cccc(Cl)c2Cl)C(=O)OC

InChI

1S/C18H19Cl2NO4/c1-5-25-18(23)14-10(3)21-9(2)13(17(22)24-4)15(14)11-7-6-8-12(19)16(11)20/h6-8,15,21H,5H2,1-4H3

InChI key

RZTAMFZIAATZDJ-UHFFFAOYSA-N

Gene Information

human ... CACNA1C(775), CACNA1D(776), CACNA1F(778), CACNA1S(779), CACNA2D1(781), NR3C2(4306)

설명

General description

Felodipine is a dihydropyridine derivative. It has diuretic properties. Felodipine has high vascular selectivity. It is used to treat hypertension. Felodipine regulates chronic stable angina.

Biochem/physiol Actions

L-type calcium channel blocker

Features and Benefits

This compound was developed by AstraZeneca. To browse the list of other pharma-developed compounds and Approved Drugs/Drug Candidates, click here.

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pictograms

GHS08,GHS07,GHS09

signalword

Warning

hcodes

H302,H361d,H373,H410

pcodes

P202 - P260 - P264 - P273 - P301 + P312 - P308 + P313

Hazard Classifications

Acute Tox. 4 Oral - Aquatic Acute 1 - Aquatic Chronic 1 - Repr. 2 - STOT RE 2 Inhalation

저장 등급

11 - Combustible Solids

wgk

WGK 3

ppe

dust mask type N95 (US), Eyeshields, Gloves

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문서 라이브러리 방문

Microstructural investigation to the controlled release kinetics of monolith osmotic pump tablets via synchrotron radiation X-ray microtomography.

Haiyan Li et al.

International journal of pharmaceutics, 427(2), 270-275 (2012-03-01)

Tomographic imaging techniques are attractive tools for the visualization of the internal structural characteristics of pharmaceutical solid dosage forms. In this paper, the internal structure of the tablet core for a monolith osmotic drug delivery system, felodipine sustained-release tablet, was

QSAR model for human pregnane X receptor (PXR) binding: screening of environmental chemicals and correlations with genotoxicity, endocrine disruption and teratogenicity.

Marianne Dybdahl et al.

Toxicology and applied pharmacology, 262(3), 301-309 (2012-05-26)

The pregnane X receptor (PXR) has a key role in regulating the metabolism and transport of structurally diverse endogenous and exogenous compounds. Activation of PXR has the potential to initiate adverse effects, causing drug-drug interactions, and perturbing normal physiological functions.

ToF-SIMS analysis of chemical heterogenities in inkjet micro-array printed drug/polymer formulations.

Nikolaos Scoutaris et al.

Journal of materials science. Materials in medicine, 23(2), 385-391 (2011-11-16)

Three different formulations comprising two drugs, felodipine and hydrochlorothiazide (HCT) and two polymers, poly(vinyl pyrolidone) (PVP) and poly(lactic-co-glycolic acid) (PLGA) were inkjet printed as micro-dot arrays and analysed on an individual micro-spot basis by time-of-flight secondary ion mass spectrometry (ToF-SIMS).

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국제 무역 품목 번호

SKU	GTIN
F9677-5MG	04061832961675
F9677-25MG	04061832961668