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F6627

5-Fluorouracil

≥99% purity (HPLC), powder

동의어(들):

2,4-Dihydroxy-5-fluoropyrimidine, 5-FU, 5-Fluoro-2,4(1H,3H)-pyrimidinedione

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제품정보 (DICE 배송 시 비용 별도)

실험식(Hill 표기법):
C4H3FN2O2
CAS 번호:
51-21-8
Molecular Weight:
130.08
NACRES:
NA.47
PubChem Substance ID:
24278439
UNSPSC Code:
12171500
EC Number:
200-085-6
MDL number:
MFCD00006018
Beilstein/REAXYS Number:
127172
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제품 이름

5-Fluorouracil, ≥99% (HPLC), powder

Quality Level

200

assay

≥99% (HPLC)

form

powder

technique(s)

titration: suitable

color

white

mp

282-286 °C (dec.) (lit.)

solubility

1 M NH4OH: soluble, DMSO/DMF: soluble, methanol: soluble

εmax

7.07 at 265 nm in 0.1 M HCl

application(s)

diagnostic assay manufacturing
hematology
histology

storage temp.

room temp

SMILES string

FC1=CNC(=O)NC1=O

InChI

1S/C4H3FN2O2/c5-2-1-6-4(9)7-3(2)8/h1H,(H2,6,7,8,9)

InChI key

GHASVSINZRGABV-UHFFFAOYSA-N

Gene Information

human ... TYMS(7298)

Application

5-Fluorouracil has been used to induce apoptosis in cells. It has been used as a chemosensitizing agent.

Biochem/physiol Actions

A potent antitumor agent that affects pyrimidine synthesis by inhibiting thymidylate synthetase, thus depleting intracellular dTTP pools. It is metabolized to ribonucleotides and deoxyribonucleotides, which can be incorporated into RNA and DNA. Treatment of cells with 5-FU leads to an accumulation of cells in S-phase and has been shown to induce p53 dependent apoptosis.

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pictograms

Skull and crossbonesHealth hazard
GHS06,GHS08

signalword

Danger

hcodes

H301,H351

Hazard Classifications

Acute Tox. 3 Oral - Carc. 2

저장 등급

6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects

wgk

WGK 3

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시험 성적서(COA)

Lot/Batch Number
128K1408
018K1026
097K1352
125K1499
119H1654

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국제 무역 품목 번호

SKUGTIN
F6627-5G04061835347698
F6627-1G04061835347681
F6627-10G04061835347674