F6300
Flumazenil
>99% (HPLC), solid, benzodiazepine receptor antagonist
동의어(들):
Ro 15-1788, Ro15-1788
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크기 선택
보기 변경
제품정보 (DICE 배송 시 비용 별도)
실험식(Hill 표기법):
C15H14FN3O3
CAS 번호:
Molecular Weight:
303.29
UNSPSC Code:
12352200
PubChem Substance ID:
NACRES:
NA.77
MDL number:
제품 이름
Flumazenil, >99% (HPLC), solid
Quality Level
assay
>99% (HPLC)
form
solid
color
white
originator
Roche
storage temp.
2-8°C
SMILES string
CCOC(=O)c1ncn-2c1CN(C)C(=O)c3cc(F)ccc-23
InChI
1S/C15H14FN3O3/c1-3-22-15(21)13-12-7-18(2)14(20)10-6-9(16)4-5-11(10)19(12)8-17-13/h4-6,8H,3,7H2,1-2H3
InChI key
OFBIFZUFASYYRE-UHFFFAOYSA-N
Gene Information
General description
Flumazenil reverses sedative and hypnotic effects of benzodiazepines. It is used to increase acquisition, enhance retention and treat amnesia in mice.
Biochem/physiol Actions
Highly specific benzodiazepine receptor antagonist.
Features and Benefits
This compound is a featured product for Neuroscience research. Click here to discover more featured Neuroscience products. Learn more about bioactive small molecules for other areas of research at sigma.com/discover-bsm.
This compound is featured on the GABAA Receptors page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.
This compound was developed by Roche. To browse the list of other pharma-developed compounds and Approved Drugs/Drug Candidates, click here.
저장 등급
11 - Combustible Solids
wgk
WGK 2
flash_point_f
Not applicable
flash_point_c
Not applicable
ppe
Eyeshields, Gloves, type N95 (US)
문서
DISCOVER Bioactive Small Molecules for Neuroscience
신경과학을 위한 생체 활성 저분자
A A Weinbroum et al.
Drug safety, 17(3), 181-196 (1997-11-05)
The worldwide expansion in the use of benzodiazepines has led to their frequent, and often inappropriate, use and to increase in their involvement in self-induced poisoning and iatrogenic overdosing. Flumazenil is a specific and competitive antagonist at the central benzodiazepine
A A Weinbroum et al.
European journal of anaesthesiology, 18(12), 789-797 (2001-12-12)
Midazolam may occasionally precipitate hostility and violence instead of tranquility. We characterized these episodes, their rate of occurrence, the potential paradoxical responders and possible predisposing circumstances among patients undergoing lower body surgery under spinal or epidural anaesthesia and midazolam sedation.
Pasquale Molinaro et al.
Molecular pharmacology, 83(1), 142-156 (2012-10-16)
Previous studies have demonstrated that the knockdown or knockout of the three Na(+)/Ca(2+) exchanger (NCX) isoforms, NCX1, NCX2, and NCX3, worsens ischemic brain damage. This suggests that the activation of these antiporters exerts a neuroprotective action against stroke damage. However
국제 무역 품목 번호
| SKU | GTIN |
|---|---|
| F6300-100MG | 04061835370252 |
| F6300-25MG | 04061835370269 |