F3422
Flt-3/Flk-2 ligand human
recombinant, expressed in E. coli, lyophilized powder, suitable for cell culture, ≥98% (SDS-PAGE and HPLC)
동의어(들):
FL
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크기 선택
보기 변경
제품정보 (DICE 배송 시 비용 별도)
biological source
human
Quality Level
recombinant
expressed in E. coli
assay
≥98% (SDS-PAGE and HPLC)
form
lyophilized powder
potency
≤1.0 ng/mL
mol wt
17.6 kDa
packaging
pkg of 5 μg
storage condition
avoid repeated freeze/thaw cycles
technique(s)
cell culture | mammalian: suitable
impurities
endotoxin, tested
UniProt accession no.
storage temp.
−20°C
Gene Information
human ... FLT3(2322)
General description
Mouse and human Flt-3 ligand share ~72% homology and both demonstrate cross-species activity.
Biochem/physiol Actions
Flt-3/Flk-2 Ligand (FL, or Flt-3L) is a transmembrane glycoprotein that binds and activates the Flt-3 receptor. Expression of Flt-3 is primarily restricted among hematopoietic cells to the most primitive progenitor cells.
Physical form
Lyophilized, 0.2 μm sterile filtered, with with 0.5x PBS.
Analysis Note
The biological activity is measured by its ability to stimulate the proliferation of human AML5 cells.
저장 등급
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
ppe
Eyeshields, Gloves, type N95 (US)
문서
Read article on hematopoietic cytokines and hematopoiesis
관련 콘텐츠
Lyman, S., et al. et al.
The Cytokine Handbook, 727-727 (1998)
R Namikawa et al.
Stem cells (Dayton, Ohio), 14(4), 388-395 (1996-07-01)
The biological activities of the ligand for the Flk2/Flt3 receptor tyrosine kinase (FL) on human hematopoietic cells are reviewed. In in vitro studies, FL shows relatively few effects by itself on the proliferation and differentiation of hematopoietic cells, but exhibits
H G Drexler et al.
Leukemia & lymphoma, 33(1-2), 83-91 (1999-04-08)
FLT3 ligand (FL) acting through its tyrosine kinase receptor FLT3 has pleiotropic and potent effects on hematopoietic cells. The well-described involvement of this ligand-receptor pair in physiological hematopoiesis raised the question whether FL and FLT3 also play a role in
국제 무역 품목 번호
| SKU | GTIN |
|---|---|
| F3422-5UG | 04061833613924 |