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D1822

Doxycycline monohydrate

Name: Doxycycline monohydrate
Brand: SIGMA

동의어(들):

6-Deoxy-5-oxytetracycline monohydrate, Doxycycline

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제품정보 (DICE 배송 시 비용 별도)

실험식(Hill 표기법):

C₂₂H₂₄N₂O₈· H₂O

CAS 번호:

17086-28-1

Molecular Weight:

462.45

NACRES:

NA.85

PubChem Substance ID:

329798712

UNSPSC Code:

51284030

MDL number:

MFCD02682958

기술 서비스

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도움 문의

속성

form

powder or crystals

Quality Level

200

antibiotic activity spectrum

Gram-negative bacteria, Gram-positive bacteria, mycoplasma, parasites

mode of action

protein synthesis | interferes

storage temp.

−20°C

SMILES string

O.C[C@@H]1[C@H]2[C@H](O)[C@H]3[C@H](N(C)C)C(O)=C(C(N)=O)C(=O)[C@@]3(O)C(O)=C2C(=O)c4c(O)cccc14

InChI

1S/C22H24N2O8.H2O/c1-7-8-5-4-6-9(25)11(8)16(26)12-10(7)17(27)14-15(24(2)3)18(28)13(21(23)31)20(30)22(14,32)19(12)29;/h4-7,10,14-15,17,25,27-29,32H,1-3H3,(H2,23,31);1H2/t7-,10+,14+,15-,17-,22-;/m0./s1

InChI key

XQTWDDCIUJNLTR-CVHRZJFOSA-N

Gene Information

human ... MMP1(4312), MMP13(4322), MMP7(4316), MMP8(4317)

설명

Application

In yeast cells, doxycycline has been used in doxycycline-inducible system for overexpression of methyltransferase Hmt1 (hnRNP methyltransferase 1).
It has been used in the doxycycline-inducible IFITM (interferon-induced transmembrane) cell lines.
It has also been used as an antimicrobial agent.

Biochem/physiol Actions

Doxycycline is a semisynthetic tetracycline that is active against bacteria, mycoplasma and protozoan parasites. It inhibits the bacterial protein synthesis by inhibiting the interaction of aminoacyl-tRNA and the bacterial ribosome.

Other Notes

Keep container tightly closed in a dry and well-ventilated place.

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Warning

저장 등급

11 - Combustible Solids

flash_point_f

Not applicable

flash_point_c

Not applicable

Hazard Classifications

Acute Tox. 4 Oral - Aquatic Chronic 3 - Repr. 2

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시험 성적서(COA)

Lot/Batch Number

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문서 라이브러리 방문

Tetracycline antibiotics: mode of action, applications, molecular biology, and epidemiology of bacterial resistance.

I Chopra et al.

Microbiology and molecular biology reviews : MMBR, 65(2), 232-60 (2001-05-31)

Tetracyclines were discovered in the 1940s and exhibited activity against a wide range of microorganisms including gram-positive and gram-negative bacteria, chlamydiae, mycoplasmas, rickettsiae, and protozoan parasites. They are inexpensive antibiotics, which have been used extensively in the prophlylaxis and therapy

Yeast Hmt1 catalyses asymmetric dimethylation of histone H3 arginine 2 in vitro.

Li HT, et al.

The Biochemical Journal, 467, 507-515 (2015)

In vitro antimicrobial susceptibility testing of bacterial enteropathogens causing traveler's diarrhea in four geographic regions.

Gomi H, et al.

Antimicrobial Agents and Chemotherapy, 45, 212-216 (2001)

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국제 무역 품목 번호

SKU	GTIN
D1822-500MG	04061833560853