C9754

Colchicine

Name: Colchicine
Brand: SIGMA

≥95% (HPLC), powder, antimitotic agent

동의어(들):

(S)-N-(5,6,7,9-Tetrahydro-1,2,3,10-tetramethoxy-9-oxobenzo[a]heptalen-7-yl)acetamide

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크기 선택

제품정보 (DICE 배송 시 비용 별도)

실험식(Hill 표기법):

C₂₂H₂₅NO₆

CAS 번호:

64-86-8

Molecular Weight:

399.44

Beilstein:

2228813

EC Number:

200-598-5

MDL number:

MFCD00078484

UNSPSC 코드:

12352200

PubChem Substance ID:

24278348

NACRES:

NA.77

주요 문서

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제품 이름

Colchicine, ≥95% (HPLC), powder

Quality Level

200

분석

≥95% (HPLC)

양식

powder

색상

white to yellow

mp

150-160 °C (dec.) (lit.)

solubility

ethanol: 50 mg/mL

SMILES string

COC1=CC=C2C(=CC1=O)[C@H](CCc3cc(OC)c(OC)c(OC)c23)NC(C)=O

InChI

1S/C22H25NO6/c1-12(24)23-16-8-6-13-10-19(27-3)21(28-4)22(29-5)20(13)14-7-9-18(26-2)17(25)11-15(14)16/h7,9-11,16H,6,8H2,1-5H3,(H,23,24)/t16-/m0/s1

InChI key

IAKHMKGGTNLKSZ-INIZCTEOSA-N

유전자 정보

human ... ABCB1(5243), CYP3A4(1576), TUBA1A(7846), TUBA1B(10376), TUBA1C(84790), TUBA3C(7278), TUBA3E(112714), TUBA4A(7277), TUBB(203068), TUBB1(81027), TUBB2A(7280), TUBB2B(347733), TUBB3(10381), TUBB4A(10382), TUBB4B(10383), TUBB6(84617), TUBB8(347688)
mouse ... Abcb1a(18671), Abcb1b(18669)

유사한 제품을 찾으십니까? 방문 제품 비교 안내

일반 설명

Colchicine is a secondary metabolite, which has anti-inflammatory properties. It is used to treat gout, crystal-induced joint inflammation, familial Mediterranean fever, Behçet disease, vasculitides and pericarditis. Colchicine inhibits cell division, intracellular vesicle motility, secretion of cytokines and chemokines. It is implicated in leukocyte diapedesis and lysosomal degranulation. Colchicine also blocks fibroblast proliferation and collagen transport to extracellular space.

애플리케이션

Colchicine has been used:

in the in vitro sister-chromatid exchange (SCE) assay
to study its in vitro antiviral, antibacterial, antifungal and cytotoxic activities
in microtubule disruption
to analyse its effects on Ca²⁺ transients from taxol-treated cells

생화학적/생리학적 작용

Antimitotic agent that disrupts microtubules by binding to tubulin and preventing its polymerization. Stimulates the intrinsic GTPase activity of tubulin. Induces apoptosis in several normal and tumor cell lines and activates the JNK/SAPK signaling pathway.

특징 및 장점

This compound is a featured product for ADME Tox research. Click here to discover more featured ADME Tox products. Learn more about bioactive small molecules for other areas of research at sigma.com/discover-bsm.

제조 메모

This product in powdered format can be stored in room temperature. Colchicine powder will darken upon exposure to light. Colchicine solutions can be sterilized by autoclaving or filtration. Sterilized solutions are stable for at least six months if protected from light. No appreciable colchicine hydrolysis occurred in neutral and slightly alkaline (pH = 8.1) solutions after storage frozen for 2 months.

픽토그램

GHS06,GHS08

신호어

Danger

유해 및 위험 성명서

H300,H340

예방조치 성명서

P202 - P264 - P270 - P280 - P301 + P310 - P405

Hazard Classifications

Acute Tox. 2 Oral - Muta. 1B

Storage Class Code

6.1A - Combustible acute toxic Cat. 1 and 2 / very toxic hazardous materials

WGK

WGK 3

Flash Point (°F)

Not applicable

Flash Point (°C)

Not applicable

개인 보호 장비

Eyeshields, Faceshields, Gloves, type P3 (EN 143) respirator cartridges

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시험 성적서(COA)

Lot/Batch Number

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문서 라이브러리에서 최근에 구매한 제품에 대한 문서를 찾아보세요.

문서 라이브러리 방문

Effect of the microtubule polymerizing agent taxol on contraction, Ca2+ transient and L-type Ca2+ current in rat ventricular myocytes

Howarth FC, et al.

The Journal of Physiology, 516(2), 409-419 (1999)

Colchicine today

Niel E and Scherrmann JM

Joint, Bone, Spine : Revue du Rhumatisme, 73(6), 672-678 (2006)

Genotoxic, cytostatic, antineoplastic and apoptotic effects of newly synthesized antitumour steroidal esters

Karapidaki I, et al.

Mutation Research. Genetic Toxicology and Environmental Mutagenesis, 675(1), 51-59 (2009)

A leukemia fusion protein attenuates the spindle checkpoint and promotes aneuploidy

Boyapati A, et al.

Blood, 109(9), 3963-3971 (2007)

Fibroblast growth factor 21 controls mitophagy and muscle mass.

Lynette J Oost et al.

Journal of cachexia, sarcopenia and muscle, 10(3), 630-642 (2019-03-22)

Skeletal muscle is a plastic tissue that adapts to changes in exercise, nutrition, and stress by secreting myokines and myometabolites. These muscle-secreted factors have autocrine, paracrine, and endocrine effects, contributing to whole body homeostasis. Muscle dysfunction in aging sarcopenia, cancer

모든 관련된 서류 보기

문서

Discover Bioactive Small Molecules for ADME/Tox

Colchicine

≥95% (HPLC), powder, antimitotic agent

크기 선택

제품정보 (DICE 배송 시 비용 별도)

주요 문서

속성

제품 이름

Quality Level

분석

양식

색상

mp

solubility

SMILES string

InChI

InChI key

유전자 정보

관련 카테고리

설명

일반 설명

애플리케이션

생화학적/생리학적 작용

특징 및 장점

제조 메모

안전성 정보

픽토그램

신호어

유해 및 위험 성명서

예방조치 성명서

Hazard Classifications

Storage Class Code

WGK

Flash Point (°F)

Flash Point (°C)

개인 보호 장비

문서

시험 성적서(COA)

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