C7291
Clomipramine hydrochloride
≥98% (HPLC), powder
동의어(들):
3-Chloro-10,11-dihydro-N,N-dimethyl-5H-dibenz[b,f]azepine-5-propanamine hydrochloride, Anafranil hydrochloride
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크기 선택
보기 변경
제품정보 (DICE 배송 시 비용 별도)
실험식(Hill 표기법):
C19H23ClN2 · HCl
CAS 번호:
Molecular Weight:
351.31
NACRES:
NA.77
PubChem Substance ID:
UNSPSC Code:
12352116
EC Number:
241-344-3
MDL number:
Quality Level
assay
≥98% (HPLC)
form
powder
color
white to off-white
solubility
H2O: 25 mg/mL, 0.1 M HCl: soluble
originator
Novartis
SMILES string
Cl.CN(C)CCCN1c2ccccc2CCc3ccc(Cl)cc13
InChI
1S/C19H23ClN2.ClH/c1-21(2)12-5-13-22-18-7-4-3-6-15(18)8-9-16-10-11-17(20)14-19(16)22;/h3-4,6-7,10-11,14H,5,8-9,12-13H2,1-2H3;1H
InChI key
WIMWMKZEIBHDTH-UHFFFAOYSA-N
Gene Information
General description
Clomipramine hydrochloride is an antiobsessional drug. It has anticholinergic activity in vitro and in vivo. Clomipramine is used to treat obsessive compulsive disorder and panic disorder.
Application
Clomipramine hydrochloride has been used to manipulate serotonin (5-HT) mechanisms. It has also been used to study its role on bone mass.
Clomipramine hydrochloride has been used:
- to study its effect on human serum albumin using UV-visible, fluorescence and circular dichroism (CD) techniques
- to block itchy E3 ubiquitin protein ligase (ITCH) ubiquitin transthiolation
- as a serotonin reuptake inhibitor
- as a homologous to E6AP C terminus (HECT) E3 ligase inhibitor
Biochem/physiol Actions
Tricyclic antidepressant; inhibits serotonin and norepinephrine transporters.
Clomipramine hydrochloride (CLP) is a amphiphilic drug, with two benzene rings in its structure. It exhibits anti-depressant property by restoring the equilibrium of certain natural materials in the human being. CLP acts as a potential therapeutic for obsessive compulsive disorder.
Features and Benefits
This compound is featured on the Biogenic Amine Transporters page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.
This compound was developed by Novartis. To browse the list of other pharma-developed compounds and Approved Drugs/Drug Candidates, click here.
signalword
Danger
hcodes
Hazard Classifications
Acute Tox. 4 Oral - Aquatic Acute 1 - Aquatic Chronic 1 - STOT SE 1 - STOT SE 3
target_organs
Central nervous system, Central nervous system,Cardiovascular
저장 등급
6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects
ppe
dust mask type N95 (US), Eyeshields, Gloves
J Ortiz et al.
British journal of pharmacology, 105(4), 941-946 (1992-04-01)
1. The concentration of 5-hydroxytryptamine (5-HT) in rat platelet-free plasma increased significantly 30 min after a single i.p. injection (10 mg kg-1) of each of six inhibitors of the high-affinity 5-HT uptake (fluvoxamine, fluoxetine, alaproclate, paroxetine, sertraline and clomipramine). The
Clomipramine causes osteoporosis by promoting osteoclastogenesis via E3 ligase Itch, which is prevented by Zoledronic acid
Li X, et al.
Scientific reports, 7, 41358-41358 (2017)
Genotoxic effect of the tricyclic antidepressant drug clomipramine hydrochloride in somatic and germ cells of male mice
El-Fiky SA, et al.
Asian Pacific Journal of Allergy and Immunology / Launched by the Allergy and Immunology Society of Thailand, 6(4), 321-327 (2016)
국제 무역 품목 번호
| SKU | GTIN |
|---|---|
| C7291-1G | 04061833512241 |
| C7291-5G | 04061833512258 |