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C6305

Clozapine

≥98% (TLC), powder, D₄-dopamine receptor antagonist

동의어(들):

8-Chloro-11-(4-methyl-1-piperazinyl)-5H-dibenzo[b,e][1,4]-diazepine

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제품정보 (DICE 배송 시 비용 별도)

실험식(Hill 표기법):
C18H19ClN4
CAS 번호:
5786-21-0
Molecular Weight:
326.82
UNSPSC Code:
12352200
PubChem Substance ID:
24277892
NACRES:
NA.77
MDL number:
MFCD00153785
Form:
powder
Quality level:
300
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제품 이름

Clozapine,

form

powder

Quality Level

300

solubility

ethanol: 1 mg/mL, 0.1 M HCl: 30 mg/mL, DMSO: 4.8 mg/mL

originator

Novartis

SMILES string

CN1CCN(CC1)C2=Nc3cc(Cl)ccc3Nc4ccccc24

InChI

1S/C18H19ClN4/c1-22-8-10-23(11-9-22)18-14-4-2-3-5-15(14)20-16-7-6-13(19)12-17(16)21-18/h2-7,12,20H,8-11H2,1H3

InChI key

QZUDBNBUXVUHMW-UHFFFAOYSA-N

Gene Information

human ... ADRA1A(148), ADRA2A(150), ADRA2C(152), CHRM1(1128), DRD2(1813), DRD3(1814), DRD4(1815), HRH1(3269), HRH4(59340), HTR2A(3356), HTR2C(3358), HTR3A(3359), HTR3B(9177), HTR3C(170572), HTR3D(200909), HTR3E(285242), HTR6(3362), HTR7(3363), KCNH1(3756), KCNH2(3757), UGT1A4(54657)
rat ... Adra1a(29412), Adra2a(25083), Adrb1(24925), Chrm1(25229), Drd1a(24316), Drd2(24318), Drd3(29238), Drd4(25432), Hrh1(24448), Htr1a(24473), Htr1b(25075), Htr2a(29595), Htr2b(29581), Htr2c(25187), Htr3a(79246), Htr7(65032), Slc6a4(25553)

Biochem/physiol Actions

Atypical antipsychotic compound. Selective antagonist for D4-dopamine receptor. Antagonist at 5-HT2A, 5-HT2C, 5-HT3, 5-HT6, and 5-HT7 serotonin receptors.

Features and Benefits

This compound is featured on the Histamine Receptors page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.
This compound was developed by Novartis. To browse the list of other pharma-developed compounds and Approved Drugs/Drug Candidates, click here.

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pictograms

Skull and crossbones
GHS06

signalword

Danger

hcodes

H301

Hazard Classifications

Acute Tox. 3 Oral

저장 등급

6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

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시험 성적서(COA)

Lot/Batch Number
010K1204
010K1206
077H4110
066H4046
055H4054

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문서 라이브러리 방문

P B Bergqvist et al.
Psychopharmacology, 143(1), 89-96 (1999-05-05)
Low doses of the atypical antipsychotic drug risperidone are effective in patients with obsessive compulsive disorder (OCD) not responding to serotonin (5-HT) reuptake inhibitors, although higher doses have been reported to induce OCD symptoms in psychotic patients. Since such atypical
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The counterregulatory response to hypoglycemia is an essential survival function. It is controlled by an integrated network of glucose-responsive neurons, which trigger endogenous glucose production to restore normoglycemia. The complexity of this glucoregulatory network is, however, only partly characterized. In
Owen Randlett et al.
Current biology : CB, 29(8), 1337-1345 (2019-04-09)
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국제 무역 품목 번호

SKUGTIN
C6305-1G04061825982106
C6305-100MG04061833511152
C6305-25MG04061833511169