C4911
Chlorothiazide
synthetic (organic), ≥98% (HPLC), carbonic anhydrase inhibitor, powder
동의어(들):
6-Chloro-2H-1,2,4-benzothiadiazine-7-sulfonamide 1,1-dioxide
조직 및 계약 가격을 보려면 로그인를 클릭합니다.
크기 선택
보기 변경
제품정보 (DICE 배송 시 비용 별도)
실험식(Hill 표기법):
C7H6ClN3O4S2
CAS 번호:
Molecular Weight:
295.72
NACRES:
NA.77
PubChem Substance ID:
UNSPSC Code:
12352202
EC Number:
200-404-9
MDL number:
제품 이름
Chlorothiazide, thiazide diuretic
biological source
synthetic (organic)
Quality Level
assay
≥98% (HPLC)
form
powder
mp
>300 °C
solubility
DMF: 50 mg/mL, clear, colorless to very faintly yellow
storage temp.
2-8°C
SMILES string
O=S(C1=C2C=C(Cl)C(S(N)(=O)=O)=C1)(NC=N2)=O
InChI
1S/C7H6ClN3O4S2/c8-4-1-5-7(2-6(4)16(9,12)13)17(14,15)11-3-10-5/h1-3H,(H,10,11)(H2,9,12,13)
InChI key
JBMKAUGHUNFTOL-UHFFFAOYSA-N
Gene Information
human ... CA1(759), CA4(762), SLC12A3(6559)
General description
Chlorothiazide (CTLD) is a thiazide-like diuretics and has antihypertensive effects.
Application
Chlorothiazide has been used as a reference standard in parallel artificial membrane permeability assay (PAMPA). It has also been used to test its effect on blocking pendrin activity.
One of the first in the thiazide class of diuretics.
Biochem/physiol Actions
Chlorothiazide (CTLD) shows structural resemblance with hydrochlorothiazide by having a sulfonamide group, but exhibits a long action duration. CTLD is an inhibitor of carbonic anhydrase and is more potent than hydrochlorothiazide.
signalword
Danger
hcodes
Hazard Classifications
Resp. Sens. 1 - Skin Sens. 1
저장 등급
11 - Combustible Solids
wgk
WGK 2
flash_point_f
Not applicable
flash_point_c
Not applicable
ppe
dust mask type N95 (US), Eyeshields, Faceshields, Gloves
Stela Dineva et al.
Journal of human hypertension, 33(11), 766-774 (2019-10-09)
Hypertension is a complex syndrome of multiple hemodynamic, neuroendocrine, and metabolic abnormalities. The goals of treatment in hypertension are to optimally control high blood pressure and to reduce associated cardiovascular morbidity and mortality using the most suitable therapy available. Hydrochlorothiazide
Emanuele Bernardinelli et al.
Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology, 38(5), 1984-1998 (2016-05-11)
Pendrin is a Cl-/I-/HCO3- exchanger playing a fundamental role in controlling blood pressure and airway function, therefore representing an attractive target for the treatment of hypertensive states and respiratory distresses. A review of the literature regarding the ability of some
Optimization of a parallel artificial membrane permeability assay for the fast and simultaneous prediction of human intestinal absorption and plasma protein binding of drug candidates: application to dibenz [b, f] azepine-5-carboxamide derivatives
Fortuna A, et al.
Journal of Pharmaceutical Sciences, 101(2), 530-540 (2012)
국제 무역 품목 번호
| SKU | GTIN |
|---|---|
| C4911-50G | 04061833493779 |