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C4042

Captopril

Name: Captopril
Brand: SIGMA

≥98% (HPLC), powder, angiotensin converting enzyme inhibitor

동의어(들):

N-[(S)-3-Mercapto-2-methylpropionyl]-L-proline

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제품정보 (DICE 배송 시 비용 별도)

실험식(Hill 표기법):

C₉H₁₅NO₃S

CAS 번호:

62571-86-2

Molecular Weight:

217.29

NACRES:

NA.77

PubChem Substance ID:

57654003

UNSPSC Code:

12352200

EC Number:

263-607-1

MDL number:

MFCD00168073

Beilstein/REAXYS Number:

477887

Assay:

≥98% (HPLC)

Form:

powder

Quality level:

100

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속성

제품 이름

Captopril, ≥98% (HPLC), powder

biological source

synthetic

Quality Level

100

assay

≥98% (HPLC)

form

powder

color

white to off-white

mp

104-108 °C (lit.)

solubility

water: 100 mg/mL, clear to very slightly hazy, colorless to faintly yellow

originator

Bristol-Myers Squibb

storage temp.

room temp

SMILES string

C[C@H](CS)C(=O)N1CCC[C@H]1C(O)=O

InChI

1S/C9H15NO3S/c1-6(5-14)8(11)10-4-2-3-7(10)9(12)13/h6-7,14H,2-5H2,1H3,(H,12,13)/t6-,7+/m1/s1

InChI key

FAKRSMQSSFJEIM-RQJHMYQMSA-N

Gene Information

human ... ACE(1636), AGTR1(185), AGTR2(186), ECE1(1889)
rat ... Ace(24310)

설명

Application

Captopril has been used:

to examine the influence of timing of captopril treatment on efficacy in transverse aortic constriction (TAC) mice
as an angiotensin-converting enzyme inhibitor and orally administered to unrestrained Wistar Kyoto rats in an approach to study its effects of angiogenesis inhibition and interdependency with other drugs
used as a positive control in spectrophotometric assay to study the angiotensin-converting enzyme inhibitory activity

Biochem/physiol Actions

Captopril is known to decrease the cardiovascular complications arising due to myocardial infarction. It is an effective drug in treating diabetic nephropathy and renal disease. Captopril acts by reducing cardiac related inflammation, fibrosis and calcification.

Angiotensin converting enzyme inhibitor. Inhibits the formation of angiotensin II, a bioactive peptide that stimulates angiogenesis and increases microvessel density.

Features and Benefits

This compound is a featured product for ADME Tox research. Click here to discover more featured ADME Tox products. Learn more about bioactive small molecules for other areas of research at sigma.com/discover-bsm.

This compound is featured on the Neuropeptidases page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.

This compound was developed by Bristol-Myers Squibb. To browse the list of other pharma-developed compounds and Approved Drugs/Drug Candidates, click here.

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pictograms

GHS08

signalword

Danger

hcodes

H341,H360F

pcodes

P201 - P202 - P280 - P308 + P313 - P405 - P501

Hazard Classifications

Muta. 2 - Repr. 1B

저장 등급

6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects

wgk

WGK 2

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

Eyeshields, Faceshields, Gloves, type P3 (EN 143) respirator cartridges

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문서

Critical Inhibitor Characteristics to Consider

Discover critical characteristics to consider when working with enzyme inhibitors, such as cell permeability, the prozone effect, and Lipinski’s rule of 5.

Discover Bioactive Small Molecules for ADME/Tox

중요하게 고려해야 할 억제제 특성

세포 투과성, 프로존 효과, 리핀스키의 5 규칙 등의 효소 억제제로 작업 시 중요하게 고려해야 할 특성을 알아보세요.

국제 무역 품목 번호

SKU	GTIN
C4042-25G	04061833487495
C4042-5G	04061833487518