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C3915

Colchicine

Name: Colchicine
Brand: SIGMA

suitable for plant cell culture, BioReagent, ≥95% (HPLC)

동의어(들):

(S)-N-(5,6,7,9-Tetrahydro-1,2,3,10-tetramethoxy-9-oxobenzo[a]heptalen-7-yl)acetamide

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제품정보 (DICE 배송 시 비용 별도)

실험식(Hill 표기법):

C₂₂H₂₅NO₆

CAS 번호:

64-86-8

Molecular Weight:

399.44

UNSPSC Code:

10171502

NACRES:

NA.72

PubChem Substance ID:

24892656

EC Number:

200-598-5

Beilstein/REAXYS Number:

2228813

MDL number:

MFCD00078484

Assay:

≥95% (HPLC)

Form:

powder

Quality level:

200

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도움 문의

속성

product line

BioReagent

Quality Level

200

assay

≥95% (HPLC)

form

powder

technique(s)

cell culture | plant: suitable

mp

150-160 °C (dec.) (lit.)

application(s)

agriculture

SMILES string

COC1=CC=C2C(=CC1=O)[C@H](CCc3cc(OC)c(OC)c(OC)c23)NC(C)=O

InChI

1S/C22H25NO6/c1-12(24)23-16-8-6-13-10-19(27-3)21(28-4)22(29-5)20(13)14-7-9-18(26-2)17(25)11-15(14)16/h7,9-11,16H,6,8H2,1-5H3,(H,23,24)/t16-/m0/s1

InChI key

IAKHMKGGTNLKSZ-INIZCTEOSA-N

Gene Information

human ... ABCB1(5243), CYP3A4(1576), TUBA1A(7846), TUBA1B(10376), TUBA1C(84790), TUBA3C(7278), TUBA3E(112714), TUBA4A(7277), TUBB(203068), TUBB1(81027), TUBB2A(7280), TUBB2B(347733), TUBB3(10381), TUBB4A(10382), TUBB4B(10383), TUBB6(84617), TUBB8(347688)
mouse ... Abcb1a(18671), Abcb1b(18669)

설명

General description

Colchicine is a tricyclic alkaloid that can stay in circulation for 20 to 40 hours post intake. Leucocytes harbour maximum colchicine. It contains three hexameric rings termed A, B and C.

Application

Colchicine has been used:

as an inhibitor of tubulin polymerization in bone-marrow-derived macrophages
for the inhibition of in vitro neurite outgrowth in human neuronal cells
as microtubule destabilizer to induce peripheral neuropathy in induced pluripotent stem cell derived neurons (iPSC-Neurons)

Biochem/physiol Actions

Colchicine interacts with albumin and binds to tubulin. Its association with tubulin impacts autophagic vacuole fusion with lysosomes. It inhibits tyrosine kinases and phospholipases. Colchicine may be useful for treating acute coronary syndromes. It is prescribed for treating rheumatologic conditions including familial mediterranean fever (FMF) and acute gouty arthritis.

Colchicine is an inhibitor of microtubule polymerization which blocks chromosome segregation during meiosis. Consequently, Colchicine is used to induce polyploidy (tetraploid) in plant cells.