C2389

Cerulenin

Name: Cerulenin
Brand: SIGMA

from Cephalosporium caerulens, ≥98% (HPLC), powder, de novo phospholipid synthesis inhibitor

동의어(들):

Helicocerin, (2R,3S,E,E)-2,3-Epoxy-4-oxo-7,10-dodecadienamide

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크기 선택

제품정보 (DICE 배송 시 비용 별도)

실험식(Hill 표기법):

C₁₂H₁₇NO₃

CAS 번호:

17397-89-6

Molecular Weight:

223.27

Beilstein:

4140423

EC Number:

241-424-8

MDL number:

MFCD00083595

UNSPSC 코드:

51111800

PubChem Substance ID:

24892323

NACRES:

NA.77

주요 문서

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도움 문의

제품 이름

Cerulenin, ≥98% (HPLC), from Cephalosporium caerulens

생물학적 소스

Cephalosporium caerulens

Quality Level

200

분석

≥98% (HPLC)

양식

powder

mp

93 °C

solubility

acetone: 19.60-20.40 mg/mL, clear to slightly hazy, colorless to yellow

항생제 활성 스펙트럼

fungi

동작 모드

enzyme | inhibits

저장 온도

−20°C

SMILES string

C/C=C/C/C=C/CCC([C@@H]1[C@H](C(N)=O)O1)=O

InChI

1S/C13H18O3/c1-3-4-5-6-7-8-9-11(15)13-12(16-13)10(2)14/h3-4,6-7,12-13H,5,8-9H2,1-2H3/b4-3+,7-6+/t12-,13+/m0/s1

InChI key

PTNNGEBMCNMENY-JIVMHGEESA-N

유전자 정보

human ... FASN(2194)

유사한 제품을 찾으십니까? 방문 제품 비교 안내

일반 설명

Cerulenin, an inhibitor of de novo phospholipid synthesis triggers apoptosis in various wild type p53 and mutant p53 tumor cell lines. This fungal antibiotic also blocks the condensing enzyme involved in fatty acid and polyketide biosynthesis.

애플리케이션

Cerulenin has been used:

as a fatty acid synthase inhibitor to study its effects on aldosterone-induced trained immunity
as a blocker of fatty acid synthase to study its effects on the replication of severe acute respiratory syndrome coronavirus 2 (SARS-CoV2)
as a supplement in yeast extract–peptone–dextrose/glycerol (YPD/G) agar plates for the isolation of cerulenin-resistant yeast strains

픽토그램

GHS07

신호어

Warning

유해 및 위험 성명서

H302

Hazard Classifications

Acute Tox. 4 Oral

Storage Class Code

11 - Combustible Solids

WGK

WGK 3

Flash Point (°F)

Not applicable

Flash Point (°C)

Not applicable

개인 보호 장비

dust mask type N95 (US), Eyeshields, Gloves

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문서 라이브러리에서 최근에 구매한 제품에 대한 문서를 찾아보세요.

문서 라이브러리 방문

Evidence for the Involvement of Fatty Acid Biosynthesis and Degradation in the Formation of Insect Sex Pheromone-Mimicking Chiloglottones in Sexually Deceptive Chiloglottis Orchids.

Darren C J Wong et al.

Frontiers in plant science, 9, 839-839 (2018-07-05)

Hundreds of orchid species secure pollination by sexually luring specific male insects as pollinators by chemical and morphological mimicry. Yet, the biochemical pathways involved in the synthesis of the insect sex pheromone-mimicking volatiles in these sexually deceptive plants remain poorly

[Mechanism of action of cerulenin on fatty acid synthetase and cerulenin resistance in a cerulenin-producing fungus].

H Tomoda et al.

Seikagaku. The Journal of Japanese Biochemical Society, 57(3), 190-201 (1985-03-01)

Malonyl-CoA mediates leptin hypothalamic control of feeding independent of inhibition of CPT-1a.

Su Gao et al.

American journal of physiology. Regulatory, integrative and comparative physiology, 301(1), R209-R217 (2011-04-22)

Hypothalamic fatty acid metabolism is involved in central nervous system controls of feeding and energy balance. Malonyl-CoA, an intermediate of fatty acid biosynthesis, is emerging as a significant player in these processes. Notably, hypothalamic malonyl-CoA has been implicated in leptin's

Electron cryomicroscopy observation of acyl carrier protein translocation in type I fungal fatty acid synthase.

Jennifer W Lou et al.

Scientific reports, 9(1), 12987-12987 (2019-09-12)

During fatty acid biosynthesis, acyl carrier proteins (ACPs) from type I fungal fatty acid synthase (FAS) shuttle substrates and intermediates within a reaction chamber that hosts multiple spatially-fixed catalytic centers. A major challenge in understanding the mechanism of ACP-mediated substrate

Cell Death Triggered by a Putative Amphipathic Helix of Radish mosaic virus Helicase Protein Is Tightly Correlated With Host Membrane Modification.

Masayoshi Hashimoto et al.

Molecular plant-microbe interactions : MPMI, 28(6), 675-688 (2015-02-05)

Systemic necrosis is one of the most severe symptoms caused by plant RNA viruses. Recently, systemic necrosis has been suggested to have similar features to a defense response referred to as the hypersensitive response (HR), a form of programmed cell

모든 관련된 서류 보기

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Fatty Acid Synthesis in Cancer Cells

Fatty acid synthesis supports cancer cell proliferation, essential for membrane generation, protein modification, and bioenergetics.

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Cholesterol Biosynthesis Regulation

Cholesterol synthesis regulation by dietary levels, LDL receptors control lipid-rich LDL particle transport in cells.

지질 신호전달 연구를 위한 생체 활성 저분자

Cerulenin

from Cephalosporium caerulens, ≥98% (HPLC), powder, de novo phospholipid synthesis inhibitor

크기 선택

제품정보 (DICE 배송 시 비용 별도)

주요 문서

속성

제품 이름

생물학적 소스

Quality Level

분석

양식

mp

solubility

항생제 활성 스펙트럼

동작 모드

저장 온도

SMILES string

InChI

InChI key

유전자 정보

관련 카테고리

설명

일반 설명

애플리케이션

안전성 정보

픽토그램

신호어

유해 및 위험 성명서

Hazard Classifications

Storage Class Code

WGK

Flash Point (°F)

Flash Point (°C)

개인 보호 장비

문서

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