주요 문서

모든 문서 보기

C1055

Cromakalim

Name: Cromakalim
Brand: SIGMA

동의어(들):

(±)-trans-6-Cyano-3,4-dihydro-2,2-dimethyl-4-(2-oxopyrrolidin-1-yl)-2H-1-benzopyran-3-ol

조직 및 계약 가격을 보려면 로그인를 클릭합니다.

크기 선택

보기 변경

제품정보 (DICE 배송 시 비용 별도)

실험식(Hill 표기법):

C₁₆H₁₈N₂O₃

CAS 번호:

94470-67-4

Molecular Weight:

286.33

NACRES:

NA.77

PubChem Substance ID:

24891962

UNSPSC Code:

12352200

MDL number:

MFCD00133201

Form:

powder

Quality level:

200

기술 서비스

도움이 필요하신가요? 저희 숙련된 과학자 팀이 도와드리겠습니다.

도움 문의

속성

form

powder

Quality Level

200

storage temp.

2-8°C

SMILES string

CC1(C)Oc2ccc(cc2[C@H]([C@@H]1O)N3CCCC3=O)C#N

InChI

1S/C16H18N2O3/c1-16(2)15(20)14(18-7-3-4-13(18)19)11-8-10(9-17)5-6-12(11)21-16/h5-6,8,14-15,20H,3-4,7H2,1-2H3/t14-,15+/m1/s1

InChI key

TVZCRIROJQEVOT-CABCVRRESA-N

Gene Information

rat ... Kcna1(24520), Kcnj1(24521), Kcnj5(29713), Kcnj8(25472)

설명

Application

Cromakalim has been used:

as a potassium channel agonist to study its response to an acute increase in downstream pressure in rat lymphatic vessels.
as a potassium channel opener to study its effects on the release of transmitters from adrenergic nerves in rat vas deferens.
as a potassium channel activator to study its effects on the release of transmitters from purinergic and cholinergic nerves in the rat detrusor muscle.

Biochem/physiol Actions

Cromakalim is an activator of the potassium channel. It is involved in the relaxation of the vascular smooth muscles. Cromakalim exhibits anti-hypertensive activity.

Features and Benefits

This compound is featured on the Potassium Channels page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.

저장 등급

11 - Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

Eyeshields, Gloves, type N95 (US)

가장 최신 버전 중 하나를 선택하세요:

시험 성적서(COA)

Lot/Batch Number

적합한 버전을 찾을 수 없으신가요?

특정 버전이 필요한 경우 로트 번호나 배치 번호로 특정 인증서를 찾을 수 있습니다.

COA 검색

이 제품을 이미 가지고 계십니까?

문서 라이브러리에서 최근에 구매한 제품에 대한 문서를 찾아보세요.

문서 라이브러리 방문

Hydrogen sulfide as an allosteric modulator of ATP-sensitive potassium channels in colonic inflammation.

Aravind R Gade et al.

Molecular pharmacology, 83(1), 294-306 (2012-11-02)

The ATP-sensitive potassium channel (K(ATP)) in mouse colonic smooth muscle cell is a complex containing a pore-forming subunit (Kir6.1) and a sulfonylurea receptor subunit (SUR2B). These channels contribute to the cellular excitability of smooth muscle cells and hence regulate the

Isoflurane pretreatment preserves adenosine triphosphate-sensitive K(+) channel function in the human artery exposed to oxidative stress caused by high glucose levels.

Hiroyuki Kinoshita et al.

Anesthesia and analgesia, 115(1), 54-61 (2012-04-03)

Adenosine triphosphate (ATP)-sensitive K(+) channels contribute to significant regulatory mechanisms related to organ blood flow in both physiological and pathological conditions. High glucose impairs arterial ATP-sensitive K(+) channel activity via superoxide production. However, the effects of anesthetics on this pathological

Eicosapentaenoic acid reduces ischemic ventricular fibrillation via altering monophasic action potential in pigs.

Ryuji Tsuburaya et al.

Journal of molecular and cellular cardiology, 51(3), 329-336 (2011-06-10)

Although high intake of n-3 fatty acids is associated with reduced mortality of patients with ischemic heart disease, especially reduction in sudden cardiac death (SCD), the detailed mechanisms remain to be elucidated. Thus, the present study was designed to examine

모든 관련된 서류 보기

국제 무역 품목 번호

SKU	GTIN
C1055-50MG	04061832574059
C1055-10MG	04061832574042