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C0424

PK 11195

Name: PK 11195
Brand: SIGMA

peripheral benzodiazepine antagonist, powder

동의어(들):

1-(2-Chlorophenyl)-N-methyl-N-(1-methylpropyl)-3-isoquinolinecarboxamide

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제품정보 (DICE 배송 시 비용 별도)

실험식(Hill 표기법):

C₂₁H₂₁ClN₂O

CAS 번호:

85532-75-8

Molecular Weight:

352.86

UNSPSC Code:

12352200

PubChem Substance ID:

24278822

NACRES:

NA.77

MDL number:

MFCD00069334

Form:

powder

Quality level:

200

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속성

제품 이름

PK 11195,

form

powder

Quality Level

200

SMILES string

CCC(C)N(C)C(=O)c1cc2ccccc2c(n1)-c3ccccc3Cl

InChI

1S/C21H21ClN2O/c1-4-14(2)24(3)21(25)19-13-15-9-5-6-10-16(15)20(23-19)17-11-7-8-12-18(17)22/h5-14H,4H2,1-3H3

InChI key

RAVIZVQZGXBOQO-UHFFFAOYSA-N

Gene Information

human ... BZRAP1(9256), TSPO(706)
rat ... Gabra2(29706), Tspo(24230)

설명

Application

PK 11195 has been used as an inhibitor of peripheral benzodiazepine receptor (PBR) homologs in primitive erythrocytes of embryos and in osteosarcoma cytoplasmic hydrids. It has also been used as an unlabelled competitive binder in in vitro autoradiography experiments in cardiac tissue sections.

Biochem/physiol Actions

PK 11195 is a peripheral benzodiazepine antagonist. It is also an antagonist for human constitutive androstane receptor (hCAR) and human pregnane X receptor (PXR). In human primary hepatocytes, PK 11195 upon demethylation elicits agonist functionality towards the receptor hCAR. PK 11195 also antagonise B-cell lymphoma 2 (Bcl-2) and may serve as a potential compound for mitochondrial targeting therapies and in the treatment of cholangiocarcinoma.

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저장 등급

11 - Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

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국제 무역 품목 번호

SKU	GTIN
C0424-10MG	04061832556116
C0424-50MG	04061832556123