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A6671

Actinonin

Name: Actinonin
Brand: SIGMA

≥98% (TLC), powder, leucine aminopeptidase inhibitor

동의어(들):

3-[[1-[(2-(Hydroxymethyl)-1-pyrrolidinyl)carbonyl]-2-methylpropyl]carbamoyl]octanohydroxamic acid

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제품정보 (DICE 배송 시 비용 별도)

실험식(Hill 표기법):

C₁₉H₃₅N₃O₅

CAS 번호:

13434-13-4

Molecular Weight:

385.50

NACRES:

NA.77

PubChem Substance ID:

24278232

UNSPSC Code:

12352200

MDL number:

MFCD00080257

Beilstein/REAXYS Number:

1555250

Assay:

≥98% (TLC)

Form:

powder

Quality level:

200

기술 서비스

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속성

제품 이름

Actinonin,

biological source

synthetic (organic)

Quality Level

200

assay

≥98% (TLC)

form

powder

solubility

ethanol: 50 mg/mL, clear, colorless

antibiotic activity spectrum

Gram-negative bacteria, Gram-positive bacteria

mode of action

enzyme | inhibits

storage temp.

−20°C

SMILES string

CCCCCC(CC(=O)NO)C(=O)NC(C(C)C)C(=O)N1CCCC1CO

InChI

1S/C19H35N3O5/c1-4-5-6-8-14(11-16(24)21-27)18(25)20-17(13(2)3)19(26)22-10-7-9-15(22)12-23/h13-15,17,23,27H,4-12H2,1-3H3,(H,20,25)(H,21,24)

InChI key

XJLATMLVMSFZBN-UHFFFAOYSA-N

Gene Information

human ... ANPEP(290), DPP4(1803), ECE1(1889), LAP3(51056)

설명

General description

Chemical structure: peptide

Application

Actinonin has been used as a control to inhibit meprin-β activity in C57BL/6 mice. It has also been used to study the high-affinity interaction of EcPDF with actinonin by 15N NMR spectroscopy and isothermal titration.

Biochem/physiol Actions

Actinonin has inhibitory action against peptide deformylase (PDF). It is effective against Gram-positive and fastidious Gram-negative microorganisms.

Actinonin is an inhibitor of leucine aminopeptidase. Actinonin has also been used to improve antibacterial activity and antiobesity therapeutics.

Features and Benefits

This compound is featured on the Neuropeptidases page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.

저장 등급

11 - Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

Eyeshields, Gloves, type N95 (US)

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문서 라이브러리 방문

Trapping conformational states along ligand-binding dynamics of peptide deformylase: the impact of induced fit on enzyme catalysis.

Sonia Fieulaine et al.

PLoS biology, 9(5), e1001066-e1001066 (2011-06-02)

For several decades, molecular recognition has been considered one of the most fundamental processes in biochemistry. For enzymes, substrate binding is often coupled to conformational changes that alter the local environment of the active site to align the reactive groups

Ligand-induced changes in the structure and dynamics of Escherichia coli peptide deformylase

Amero CD, et al.

Biochemistry, 48(32), 7595-7607 (2009)

Formyl peptide receptor-mediated proinflammatory consequences of peptide deformylase inhibition in Staphylococcus aureus.

Diana Mader et al.

Microbes and infection, 12(5), 415-419 (2010-02-17)

The biosynthesis of proteins with N-terminal formylated methionine residues and subsequent protein deformylation are unique and invariant bacterial processes. They are exploited by the capacity of the human innate immune system to sense formylated peptides (FPs) and targeted by the

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국제 무역 품목 번호

SKU	GTIN
A6671-25MG	04061833382646
A6671-10MG	04061833258477