A6671
Actinonin
≥98% (TLC), powder, leucine aminopeptidase inhibitor
동의어(들):
3-[[1-[(2-(Hydroxymethyl)-1-pyrrolidinyl)carbonyl]-2-methylpropyl]carbamoyl]octanohydroxamic acid
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크기 선택
제품정보 (DICE 배송 시 비용 별도)
실험식(Hill 표기법):
C19H35N3O5
CAS 번호:
Molecular Weight:
385.50
Beilstein:
1555250
MDL number:
UNSPSC 코드:
12352200
PubChem Substance ID:
NACRES:
NA.77
제품 이름
Actinonin,
생물학적 소스
synthetic (organic)
Quality Level
분석
≥98% (TLC)
양식
powder
solubility
ethanol: 50 mg/mL, clear, colorless
항생제 활성 스펙트럼
Gram-negative bacteria
Gram-positive bacteria
동작 모드
enzyme | inhibits
저장 온도
−20°C
SMILES string
CCCCCC(CC(=O)NO)C(=O)NC(C(C)C)C(=O)N1CCCC1CO
InChI
1S/C19H35N3O5/c1-4-5-6-8-14(11-16(24)21-27)18(25)20-17(13(2)3)19(26)22-10-7-9-15(22)12-23/h13-15,17,23,27H,4-12H2,1-3H3,(H,20,25)(H,21,24)
InChI key
XJLATMLVMSFZBN-UHFFFAOYSA-N
유전자 정보
human ... ANPEP(290), DPP4(1803), ECE1(1889), LAP3(51056)
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일반 설명
Chemical structure: peptide
애플리케이션
Actinonin has been used as a control to inhibit meprin-β activity in C57BL/6 mice. It has also been used to study the high-affinity interaction of EcPDF with actinonin by 15N NMR spectroscopy and isothermal titration.
생화학적/생리학적 작용
Actinonin has inhibitory action against peptide deformylase (PDF). It is effective against Gram-positive and fastidious Gram-negative microorganisms.
Actinonin is an inhibitor of leucine aminopeptidase. Actinonin has also been used to improve antibacterial activity and antiobesity therapeutics.
특징 및 장점
This compound is featured on the Neuropeptidases page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.
Storage Class Code
11 - Combustible Solids
WGK
WGK 3
Flash Point (°F)
Not applicable
Flash Point (°C)
Not applicable
개인 보호 장비
Eyeshields, Gloves, type N95 (US)
Sonia Fieulaine et al.
PLoS biology, 9(5), e1001066-e1001066 (2011-06-02)
For several decades, molecular recognition has been considered one of the most fundamental processes in biochemistry. For enzymes, substrate binding is often coupled to conformational changes that alter the local environment of the active site to align the reactive groups
Ligand-induced changes in the structure and dynamics of Escherichia coli peptide deformylase
Amero CD, et al.
Biochemistry, 48(32), 7595-7607 (2009)
Diana Mader et al.
Microbes and infection, 12(5), 415-419 (2010-02-17)
The biosynthesis of proteins with N-terminal formylated methionine residues and subsequent protein deformylation are unique and invariant bacterial processes. They are exploited by the capacity of the human innate immune system to sense formylated peptides (FPs) and targeted by the
Asmaa Sina et al.
Cancer letters, 279(2), 171-176 (2009-03-07)
Recent profiling has identified the aminopeptidase N/CD13 inhibitor actinonin as a selective soluble secreted matrix metalloproteinase (MMP) inhibitor. Given that actinonin's effects against membrane-bound MMPs remain unknown and that MT1-MMP has been linked to chemo- and radio-therapy resistance in brain
Actinonin, a naturally occurring antibacterial agent, is a potent deformylase inhibitor
Chen DZ, et al.
Biochemistry, 39(6), 1256-1262 (2000)
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