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A6011

Acetazolamide

synthetic, ≥99%, carbonic anhydrase inhibitor, powder

동의어(들):

5-Acetamido-1,3,4-thiadiazole-2-sulfonamide, N-(5-Sulfamoyl-1,3,4-thiadiazol-2-yl)acetamide, N-(5-[Aminosulfonyl]-1,3,4-thiadiazol-2-yl)acetamide

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제품정보 (DICE 배송 시 비용 별도)

실험식(Hill 표기법):
C4H6N4O3S2
CAS 번호:
59-66-5
Molecular Weight:
222.25
NACRES:
NA.77
PubChem Substance ID:
57653866
UNSPSC Code:
12352202
EC Number:
200-440-5
MDL number:
MFCD00003105
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제품 이름

Acetazolamide, ≥99%, powder

biological source

synthetic

Quality Level

200

assay

≥99%

form

powder

pKa 

7.2

mp

258-259 °C

solubility

1 M NH4OH: 50 mg/mL, DMSO: soluble, methanol and ethanol: slightly soluble

SMILES string

CC(=O)Nc1nnc(s1)S(N)(=O)=O

InChI

1S/C4H6N4O3S2/c1-2(9)6-3-7-8-4(12-3)13(5,10)11/h1H3,(H2,5,10,11)(H,6,7,9)

InChI key

BZKPWHYZMXOIDC-UHFFFAOYSA-N

Gene Information

human ... CA1(759), CA12(771), CA14(23632), CA2(760), CA3(761), CA4(762), CA5A(763), CA5B(11238), CA9(768)
mouse ... Car13(71934), Car5a(12352)
rat ... Car2(54231), Car4(29242)

Application

Carbonic anhydrase inhibitor; increases cerebral blood flow.
Acetazolamide has been used:
  • to study its protective effect on steatotic liver grafts against cold ischemia reperfusion injury{49)
  • to determine its ability to bind isolated porcine retinal pigment epithelium (RPE) melanin by cassette dosing and rapid equilibrium dialysis inserts
  • to validate the in vitro gastrulation model of P19C5 stem cells for developmental toxicity screening assays
  • to study its inhibitory effect on melanogenesis through enzyme kinetic, in vitro, in vivo and in silico analyses in zebrafish and in A375 human melanoma cells

Biochem/physiol Actions

Inhibits water permeability of membranes by interacting with aquaporins
Acetazolamide is a member of sulfonamide drug family. It as an ability to inhibit the activity of carbonic anhydrase. It rapidly increases cerebral blood flow (CBF) and is used as an investigative tool in CBF studies. Acetazolamide acts as a therapeutic agent for epilepsy, glaucoma and pseudotumor cerebri.

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pictograms

Exclamation mark
GHS07

signalword

Warning

hcodes

H315,H319

Hazard Classifications

Eye Irrit. 2 - Skin Irrit. 2

저장 등급

11 - Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

dust mask type N95 (US), Eyeshields, Gloves

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시험 성적서(COA)

Lot/Batch Number
088K0810
117K0720
091K1486
084H0716
076K0671

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문서 라이브러리 방문

Gianfranco Bazzu et al.
Analytical chemistry, 81(6), 2235-2241 (2009-02-19)
A miniaturized biotelemetric device for the amperometric detection of brain tissue oxygen is presented. The new system, derived from a previous design, has been coupled with a carbon microsensor for the real-time detection of dissolved O(2) in the striatum of
Effect of acetazolamide on cerebral blood flow and cerebral metabolic rate for oxygen.
Vorstrup S, et al.
The Journal of Clinical Investigation, 74(5), 1634-1639 (1984)
Acetazolamide inhibits the level of tyrosinase and melanin: an enzyme kinetic, in vitro, in vivo, and in silico studies
Abbas Q, et al.
Chemistry and Biodiversity, 14(9), e1700117-e1700117 (2017)
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국제 무역 품목 번호

SKUGTIN
A6011-10G04061833376713
A6011-100G04061832945286
A6011-250G04061832945293
A6011-25G04061833376775