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A5835

γ-Aminobutyric acid

Name: &#947;-Aminobutyric acid
Brand: SIGMA

≥99%, suitable for ligand binding assays, BioXtra

동의어(들):

3-Carboxypropylamine, 4-Aminobutanoic acid, GABA, Piperidic acid, Piperidinic acid

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제품정보 (DICE 배송 시 비용 별도)

Linear Formula:

NH₂(CH₂)₃COOH

CAS 번호:

56-12-2

Molecular Weight:

103.12

NACRES:

NA.26

PubChem Substance ID:

24891025

UNSPSC Code:

12352106

EC Number:

200-258-6

MDL number:

MFCD00008226

Beilstein/REAXYS Number:

906818

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속성

제품 이름

γ-Aminobutyric acid, BioXtra, ≥99%

product line

BioXtra

Quality Level

200

assay

≥99%

form

powder

technique(s)

ligand binding assay: suitable

impurities

<0.0005% Phosphorus (P), <0.1% Insoluble matter

ign. residue

<0.1%

color

white

mp

195 °C (dec.) (lit.)

solubility

H₂O: 0.5 M at 20 °C, clear, colorless

anion traces

chloride (Cl^-): <0.04%, sulfate (SO₄^2-): <0.05%

cation traces

Al: <5 mg/kg, Ca: <20 mg/kg, Cu: <5 mg/kg, Fe: <5 mg/kg, K: <50 mg/kg, Mg: <50 mg/kg, NH₄⁺: <500 mg/kg, Na: <70 mg/kg, Pb: <10 mg/kg, Zn: <5 mg/kg

SMILES string

NCCCC(O)=O

InChI

1S/C4H9NO2/c5-3-1-2-4(6)7/h1-3,5H2,(H,6,7)

InChI key

BTCSSZJGUNDROE-UHFFFAOYSA-N

Gene Information

human ... SLC6A1(6529), SLC6A11(6538), SLC6A12(6539)
rat ... Gabra1(29705), Gabra2(29706), Olr1750(294204), Slc6a1(79212), Slc6a12(50676)

설명

General description

γ-Aminobutyric acid (GABA) is a non-protein amino acid associated with the brain. Being synthesized in the nervous system, it is packed into synaptic vesicles. It is present naturally in green tea, soybean, germinated rice, and in some fermented foods.

Application

γ-Aminobutyric acid (GABA) has been used to treat dorsal root ganglion neurons for electrophysiological recordings studies to test its effect on neuropathic pain in rats. It has also been used to test its protective effects in an ex vivo machine perfusion system of small-for-size grafts (SFSG) injury model.

Biochem/physiol Actions

γ-Aminobutyric acid (GABA) is a mammalian inhibitory neurotransmitter with multiple functions. It is crucial for the normal central nervous system (CNS) functioning. A few documented functions of GABA include its protective role in toxin-induced damage. It also elicits anti-hypertensive, anti-diabetic, anti-microbial, antioxidant, anti-allergy, anti-inflammatory, and anti-cancer effects. GABA might show beneficial effects on stress and sleep in humans. γ-Aminobutyric acid (GABA) is used to study the biological and biochemical processes mediated via the GABA receptors, GABAA and GABAB.

Major inhibitory neurotransmitter in brain; GABA_A and GABA_Breceptor agonist; increases Cl⁻ conductance.

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저장 등급

11 - Combustible Solids

wgk

WGK 1

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

dust mask type N95 (US), Eyeshields, Gloves

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문서 라이브러리 방문

Effects of Oral Gamma-Aminobutyric Acid (GABA) Administration on Stress and Sleep in Humans: A Systematic Review.

Piril Hepsomali et al.

Frontiers in neuroscience, 14, 923-923 (2020-10-13)

Gamma-aminobutyric acid (GABA) is a non-proteinogenic amino acid and is the main inhibitory neurotransmitter in the mammalian brain. GABA's stress-reducing, and sleep enhancing effects have been established. However, although several human clinical trials have been conducted, results regarding the role

Effects of niflumic acid on γ-aminobutyric acid-induced currents in isolated dorsal root ganglion neurons of neuropathic pain rats.

Li-Jie Wang et al.

Experimental and therapeutic medicine, 14(2), 1373-1380 (2017-08-16)

Niflumic acid (NFA) is a type of non-steroidal anti-inflammatory drug. Neuropathic pain is caused by a decrease in presynaptic inhibition mediated by γ-aminobutyric acid (GABA). In the present study, a whole-cell patch-clamp technique and intracellular recording were used to assess

A disinhibitory mechanism biases Drosophila innate light preference.

Weiqiao Zhao et al.

Nature communications, 10(1), 124-124 (2019-01-12)

Innate preference toward environmental conditions is crucial for animal survival. Although much is known about the neural processing of sensory information, how the aversive or attractive sensory stimulus is transformed through central brain neurons into avoidance or approaching behavior is

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국제 무역 품목 번호

SKU	GTIN
A5835-100G	04061833376515
A5835-10G	04061833376522
A5835-10MG	04061833617021
A5835-25G	04061833376539