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Merck

A4599

L-Arginine monohydrochloride

동의어(들):

(S)-(+)-2-Amino-5-[(aminoiminomethyl)amino]pentanoic acid monohydrochloride, (S)-(+)-Arginine hydrochloride

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제품정보 (DICE 배송 시 비용 별도)

실험식(Hill 표기법):
C6H14N4O2 · HCl
CAS 번호:
Molecular Weight:
210.66
EC Number:
214-275-1
UNSPSC Code:
12352209
NACRES:
NA.26
Beilstein/REAXYS Number:
3631658
MDL number:
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biological source

non-animal source

Quality Level

assay

≥98.5%

form

crystalline powder

technique(s)

cell culture | mammalian: suitable

impurities

endotoxin, heavy metals, residual solvents, tested

solubility

H2O: 100 mg/mL

density

1.42 g/cm3 at 20 °C

anion traces

chloride (Cl-): 16.58-17.00%, sulfate (SO42-): ≤0.020%

cation traces

As: ≤1.0 ppm, NH4+: ≤0.02%, heavy metals: ≤10 ppm

application(s)

pharmaceutical (small molecule)

foreign activity

cytotoxicity, tested

General description

Our SAFC® portfolio of high-quality raw materials for use in biopharmaceutical processing withstands strict quality control procedures plus the documentation and expertise to help our customers meet requirements as defined by the M-Clarity Program.

M-Clarity Program

Our comprehensive portfolio of upstream process chemicals not only provides biopharmaceutical manufacturers with high-quality raw materials for production of classical and novel therapies, but also helps them get to market faster and simplify regulatory challenges. Trust us to deliver supply chain transparency and reliable sourcing around the globe, streamlining your product qualification with best-in-class regulatory support and service.
To request documentation for this product, please contact Customer Support and select ‘Product Documentation′. Please note that access to the documentation for this product requires a confidentiality disclosure agreement.

Application

L-Arginine is a non-essential amino acid. It is used as a cell culture media component for the commercial biomanufacture of therapeutic recombinant proteins and monoclonal antibodies. L-Arginine monohydrochloride is a modified version of L-Arginine with improved solubility.

Biochem/physiol Actions

Substrate of nitric oxide synthase, which is converted to citrulline and nitric oxide (NO). Induces insulin release by a nitric oxide-dependent mechanism.

Legal Information

SAFC is a registered trademark of Merck KGaA, Darmstadt, Germany


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저장 등급

11 - Combustible Solids

flash_point_f

Not applicable

flash_point_c

Not applicable

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문서 라이브러리 방문



Ilaria Canobbio et al.
The Biochemical journal, 462(3), 513-523 (2014-07-02)
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Carolina Di Somma et al.
Endocrine, 49(2), 492-502 (2014-11-10)
The aim of the study is to clarify the relationship between adipose tissue dysfunction, metabolic profile and growth hormone (GH)/insulin-like growth factor (IGF)-I secretion in healthy adult subjects. We investigated the metabolic profile in a cohort of 231 consecutive healthy
C B Christiansen et al.
Hormone and metabolic research = Hormon- und Stoffwechselforschung = Hormones et metabolisme, 47(7), 537-543 (2015-01-21)
TLQP-21 is a VGF-derived neuropeptide proposed to be involved in regulation of metabolism. More specifically it has been suggested that TLQP-21 has the ability to enhance glucose stimulated insulin secretion, making it a candidate for treatment of patients with type



국제 무역 품목 번호

SKUGTIN
A4599-100G04061834352471
A4599-1KG04061833374771
A4599-10KG04061834410904
A4599-25KG04061834410911
A4599-A150X04061834178781
A4599-A150XCONF04061834178798